Insights into antigen specific CD8+ T cell exhaustion
Journal Title: Biomedical Transformation - Year 2024, Vol 5, Issue 2
Abstract
CD8+ T cells are the primary mediators of antigen-specific immune responses, with their functional states finely regulated by molecular mechanisms, playing a crucial role in tumor immunity. In recent years, CD8+ T-cell-based cellular therapies (e.g., TCR-T and CAR-T cell therapy) and immune checkpoint therapies that block PD-1 signaling pathway have achieved unprecedented success in clinical cancer treatments. However, the therapeutic effects of these immunotherapies are still limited, mainly due to immune resistance, with a significant factor being the functional exhaustion of tumor antigen-specific CD8+ T cells. Consequently, a major focus and challenge in immunotherapy research is to understand the regulatory mechanisms behind this functional exhaustion and to develop intervention strategies and targets to enhance CD8+ T cell effector functions. This article reviews the research progress in antitumor immune responses of CD8+ T cells from three perspectives: The heterogeneity of exhausted CD8+ T cells, their response to PD-1 immune checkpoint blockade (ICB), and their epigenetic characteristics.
Authors and Affiliations
Liu Jiaqi, Li Yuqing, Ye Lilin, Xu Lifan
Keywords
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- EP ID EP766000
- DOI 10.12287/j.issn.2096-8965.20240208
- Views 11
- Downloads 0
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