Insilico gene expression and protein structure a comparative study on polycystic ovarian syndrome and ovarian cancer in human beings using bioinformatics
Journal Title: International Journal of Novel Trends in Pharmaceutical Sciences - Year 2015, Vol 5, Issue 3
Abstract
Ovarian cancer is a cancer that begins in an ovary. It results in abnormal cells that have the ability to invade or spread to other parts of the body. Polycystic ovary syndrome (PCOS) is a set of symptoms due to a hormone imbalance in women. PCOS is due to a combination of genetic and environmental factors. The aim of our present research investigation is to focus on gene expression and molecular structural relationships between Polycystic Ovarian Syndrome and Ovarian Cancer using advanced Insilico protocols. We identify the protein targets YAP1 (Yes Associated Protein 1) and FILIPIL (Filamin A Interacting Protein 1 Like) which are potential drug target for Polycystic Ovarian Syndrome and Ovarian Cancer. The three dimensional structure comparison studies clearly show that the two proteins target have similar sequence and structure. The identified protein target and Insilico gene expression studies would be useful in the field of clinical oncology.
Authors and Affiliations
Surya Prabha. U , Sakila. L , Balaji. M
Keywords
Related Articles
- EP ID EP91007
- DOI -
- Views 129
- Downloads 0
A study on active and passive behavioural pattern of Macaca silenus (Lion Tailed Macaque) on and off display in Aringnar Anna Zoological Park
Behaviour is the range of actions and mannerisms made by individuals in conjunction with themselves or their environment, which includes the other systems or organisms around as well as the physical environment. Studying...
RP-HPLC method development and validation of valizodone in pure and tablet dosage form
A simple, precise, rapid, accurate and economic reverse phase high performance liquid chromatographic method has been developed for the estimation ofValizodone in tablet dosage form. The separation was achieved by using...
Identification of antigenic sites presents in the TSHR protein (Hyperthyroidism -TSHR) using Insilico techniques
Hyperthyroidism affects about 1.2% of the US population. About half of these cases have obvious symptoms while the other half do not. It occurs between two and ten times more often in women. The disease is more common in...
Study of In Silico Drug Docking for Tegumental H17G Protein and Oncosphere TSO45-2A Protein in Taenia Solium (Linnaeus, 1758) using Bioinformatics Tools
Parasitic infections are most common now-a-days which arise as a global problem. Inflammation is due to the human’s immune system response to the dying cysts. Antibiotics such as Mebandazole and Albendazole have been fou...
Method development and validation of RP-HPLC Method for determination of new Antipsychotic agent in Paliperidone Palmitate bulk drug
A simple, precise, rapid ,reproducible, accurate and stability indicating RP-HPLC method has been developed for the determination of new antipsychotic agent paliperidone in pharmaceutical formulation. zorbax –SB-phenyl...