Insulin resistance assessment in patients with polycystic ovary syndrome using different diagnostic criteria – Impact of metformin treatment
Journal Title: Annals of Agricultural and Environmental Medicine - Year 2013, Vol 20, Issue 3
Abstract
Introduction and objective: Polycystic ovary syndrome (PCOS) is one of the most frequent reasons for anovulation in infertile women. It can affect 5% – 10% of women of reproductive age. One of the important factors associated with the typical clinical signs and hormonal disorders could be insulin resistance and hyperinsulinaemia. The primary objective of this study was to assess the prevalence of insulin resistance in PCOS women. The secondary objective was to evaluate changes in body mass index (BMI), waist-to-hip ratio (WHR), and insulin sensitivity after 3 months of metformin therapy Materials and methods: 68 patients were enrolled in the study. In all participants fasting and 2-h post-load glucose and insulin levels, WHR and BMI were evaluated before and after metformin (2 x 850 mg) therapy. Insulin resistance was assessed using G0/I0, G120/I120, and HOMA-IR indexes Results: Before the treatment, insulin resistance was observed in 26% patients according to HOMA-IR, and in 16% or 28% according to G[sub]0[/sub]/I[sub]0[/sub] or G[sub]120[/sub]/I[sub]120[/sub], respectively. Metformin therapy was associated with improvement in insulin sensitivity in HOMA-IR and G[sub]120[/sub]/I[sub]120[/sub] defined insulin resistant patients. Conclusions: The percentage of insulin resistant PCOS patients differed depending on the method applied. It is necessary to find a single most useful method to measure insulin resistance. Metformin treatment significantly improves insulin sensitivity in insulin resistant patients.
Authors and Affiliations
Jolanta Nawrocka-Rutkowska, Sylwester Ciecwiez, Aleksandra Marciniak, Agnieszka Brodowska, Berenika Wiśniewska, Dariusz Kotlega, Andrzej Starczewski
Passive smoking as an environmental health risk factor
Initially, tobacco was considered as a decorative plant and only later began to be treated as a herb with special therapeutic properties. With time, it was found that tobacco had strong insecticidal and addictive propert...
Treatment of lower limb trophic ulcers using hyperbaric oxygenation
[b]Introduction.[/b] Lower limb venous ulcers affect approximately 1–1.3% of the population and constitute the most dangerous and distressing complication related to chronic venous insufficiency. Although the issue of tr...
Tobacco-related Foetal Origin of Adult Diseases Hypothesis - population studies in Poland
Epidemiological studies in Poland show that tobacco smoking by adolescents at reproductive age is still frequently observed. This concerns both boys and girls. The study was based on all-Polish population studies of heal...
Evaluation of the effect of various concentrations of selected pyrethroids on the development of Dermacentor reticulatus eggs and larvae
The Palearctic three-host species[i] Dermacentor reticulatus [/i]contributes to the circulation of numerous pathogens in the environment. Reduction of its abundance may therefore decrease the risk of tick-borne diseases...
Exposure to airborne microorganisms and endotoxin in a potato processing plant.
Microbiological air sampling was performed in a big potato processing plant located in eastern Poland. Air samples for determination of concentrations of microorganisms, dust and endotoxin were collected at 6 sites in th...