Interleukin 2 and Interleukin 6 Profile in Women with Spontaneous Recurrent Abortions and As Predictor of Pregnancy Outcome
Journal Title: Journal of Medical Science And clinical Research - Year 2015, Vol 3, Issue 9
Abstract
Introduction: Successful pregnancy is dependent on T helper type-2 immunity (IL6), helpful in maintaining pregnancy, while T-helper type-I activity (IL2) is responsible for deleterious effect on pregnancy. Objective: To compare the cytokines IL2 and IL6 in cases of unexplained recurrent spontaneous abortions with those who had a successful pregnancy and with those who had a consequent abortion. Material & Methods: Group I- The patients with recurrent spontaneous unexplained abortion in first trimester (n=60) were subdivided in 2 subgroups: a) who subsequently continued pregnancy (n=40) and b) who aborted (n=20). Group II – 40 pregnant women in first trimester who delivered at term without any history of abortion were taken as controls. Blood was collected and analysed for IL2 and IL6 by ELISA kit. Parametric one way analysis of variance was used along with multiple range test (SNK) if necessary for statistical analysis. Result: IL2 (Th1) activity was higher in recurrent spontaneous abortion group weather they continued their pregnancy or aborted in comparison to control (p< .0001). On the other hand Th2 activity was insignificantly decreased (IL6) in both the groups of recurrent aborters in comparison to control. Conclusion: Recurrent Spontaneous aborters have a definite increase in Th1 activity and decreased Th2 activity irrespective of whether they aborted or continued their pregnancy in comparison to controls.
Authors and Affiliations
Shuchi Jain
Keywords
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