Interleukin-6: A promising disease severity index for dengue virus infection
Journal Title: Asian Pacific Journal of Tropical Disease - Year 2017, Vol 7, Issue 5
Abstract
Objective: To study the relationship between expression of interleukin-6 (IL-6) in serum samples and dengue virus (DV) infection in Pakistani population. Methods: This study involved three different groups, namely, DV2-infected DF patients (n = 30), DHF patients (n = 30) and healthy subjects (n = 30). Quantification of IL-6 expression in human serum samples among all the three groups from Pakistan was done by ELISA method. Other demographic findings, clinical parameters and symptoms were recorded and reported in the study. Results: IL-6 expression in DHF group (mean value = 523.23 pg/mL) was significantly higher than that in DF group (mean value = 88.83 pg/mL) and healthy subjects (mean value = 6.72 pg/ mL). Our data suggested that IL-6 level was considerably elevated (P < 0.01) with severe DV infection leading to fatal outcome in DHF patients as compared to DF and control group. Conclusions: Our findings indicate that the up-regulation of IL-6 has a significant role towards DHF, suggesting it as a prognostic marker for severe DV infection.
Nephritic syndrome and anasarca in a case of lymphatic fiariasis: A rare association
Lymphatic filariasis is caused by a nematode, namely, Wuchereria bancrofti, Brugia malayi and Brugia timori. Lymphatic filariasis is a spectrum of illness and can manifest as, asymptomatic microfilaria, acute lymphatic f...
Evaluation of gastric anti-ulcer activity of methanolic extract of Cayratia trifolia in experimental animals
Objective: To evaluate the gastric anti-ulcer activity of methanolic extract of Cayratia trifolia L. (MECT) (Vitaceae) leaves in experimental animals. Methods: MECT was investigated in pylorus ligation and ethanol induce...
Tuberculosis, hepatitis C and hepatitis B co-infections in patients with HIV in the Great Tehran Prison, Iran
We conducted a study to evaluate tuberculosis (TB), hepatitis C and hepatitis B co-infections in male patients with HIV in the Great Tehran Prison from October 2013 to May 2014. Among 85 HIV positive patients, five perso...
Prebiotic effect of Jerusalem artichoke (Helianthus tuberosus) fructans on the growth performance of Bifiobacterium bifium and Escherichia coli
Objective: To investigate and compare in vitro prebiotic effects of Jerusalem artichoke polyfructans on the survivability and activity of Bifiobacterium bifium and Escherichia coli with high performance-inulin (a high mo...
A current status of adaptogens: natural remedy to stress
Stress is a normal part of everyday life but it is important to be able to use tools for its management otherwise chronic stress, if left untreated, can lead to a variety of stress related illnesses including hypertensio...