Interleukin-6, Creatine Kinase, and Antioxidant Enzyme Activities following Platelet- Rich Plasma Treatment on Muscle Injury: A Pilot Study

Journal Title: International Journal of Applied Exercise Physiology - Year 2016, Vol 5, Issue 2

Abstract

The aim of this study was to investigate the effect of autologous platelet-rich plasma (PRP) treatment alongside rehabilitation compared with rehabilitation alone on inflammatory cytokine (interleukin-6, IL-6), creatine kinase muscle type (CKM), and antioxidant enzymes (superoxide dismutase, SOD; catalase, CAT) following hamstring injury. This study was a randomised control trial. Participants diagnosed with grade-2 acute hamstring injury (n=16) were divided into 2 groups of PRP treatment with rehabilitation program (PRP-T) and rehabilitation program (CON). Blood samples were collected at baseline, and 2 fortnightly for the various biochemical assessments. Participants were certified to have recovered upon fulfilling return to play (RTP) criteria. Level of IL-6 and the activities of CKM, SOD, and CAT were measured. PRP-T group benefited from earlier time to RTP with significantly lower IL-6 level and CAT activity compared to CON group. There was no significant difference in CKM and SOD activities between the groups, though a trend of lower values in all variables was observed at week 4 compared to week 0. PRP treatment potentially improves muscle healing process by altering both the inflammatory and oxidative responses, hence hastens time to RTP.

Authors and Affiliations

Lingling Lai, Ashril Yusof, Hamid M. S. A, Selina Khoo, A. M Nahar

Keywords

Related Articles

The Effects of High Intensity Interval Training on Mir-23a Expression and Related Factors Involved in Muscular Atrophy of Aged Rats

Among the epigenetical factors involved in muscular atrophy, Mir-23a is subjected to change due to an alternation in intercellular calcium levels. The aim of this study is to investigate the chronic effect of high intens...

The impact of fitness aerobics on the special performance and recovery processes of boys and girls 16-17 years old engaged in volleyball

Introduction: The development of special performance of athletes is a prerequisite for high-quality game. One of the means to improve the special performance of athletes in volleyball may be the use of fitness aerobics....

The effect of eight weeks occlusion strength training on oxidative stress responses to a graded maximal exercise test in overweight men

Low-intensity strength training with vascular occlusion was reported to result in muscle hypertrophy and strength increases similar to high-intensity training without occlusion. The effects of occlusion strength training...

Effects of Water and Land-based Sensorimotor Training Programs on Static Balance among University Students

This study examined the effect of sensorimotor training on static balance in two different environments; in water and on land. Thirty non-clinical university male students (aged 22±0.85 years) were divided randomly into...

Short-Term Adaptation of Some Iron Indices of Young Elite Wrestlers to Three Types of Aerobic, Anaerobic, and Wrestling Training

The central role of iron in oxygen transport makes it a key element for sports performance. Since acid-based balance is among the most important functions conducted by iron and the dominant energy system in wrestling dep...

Download PDF file
  • EP ID EP567730
  • DOI -
  • Views 184
  • Downloads 0

How To Cite

Lingling Lai, Ashril Yusof, Hamid M. S. A, Selina Khoo, A. M Nahar (2016). Interleukin-6, Creatine Kinase, and Antioxidant Enzyme Activities following Platelet- Rich Plasma Treatment on Muscle Injury: A Pilot Study. International Journal of Applied Exercise Physiology, 5(2), 1-11. https://www.europub.co.uk/articles/-A-567730