INTERNATIONAL SOCIETY ON THROMBOSIS AND HAEMOSTASIS DISSEMINATED INTRAVASCULAR COAGULATION SCORING SYSTEM: IS IT A GOOD PROGNOSTIC INDICATOR IN DIC
Journal Title: International Journal of Medical Research & Health Sciences (IJMRHS) - Year 2015, Vol 4, Issue 3
Abstract
Background: Disseminated intravascular coagulation is an acquired disorder characterized by intravascular activation of coagulation due to variety of causes. There is excessive thrombin formation leading to fibrin deposition in microcirculation and consequent ischemic organ damage. The diagnosis is essentially clinical supported by laboratory parameters and a scoring system based on these. The mainstay of treatment is correction of underlying cause and haemostatic support with replacement of coagulation factors. Aim: To evaluate the use of ISTH DIC scoring system in patients of clinically suspected Disseminated Intravascular Coagulation. Methods: 60 cases were studied over a period of one year. Patients were selected with a clinical suspicion of DIC who are having an underlying predisposing condition. Clinical signs and symptoms were recorded. Routine investigations and the tests necessary to calculate the ISTH score i.e. platelet count, Prothrombin time; D-dimer and Fibrinogen were done. The scoring criteria of ISTH were applied in these cases. Chi square and Fisher’s exact tests were used for analysis of the data. Results: The commonest cause of the underlying disorder in our study was found to be Sepsis (66.7%) followed by trauma (10%), obstetric causes (8.3%) and solid malignancy (6.7%). There was a significant association of ISTH score with outcome of the patients (P value <0.05). Raised APTT and presence of schistocytes also had a significant association with a high ISTH score. Conclusion: ISTH DIC scoring criteria more precisely define clinical and laboratory parameters of DIC. Its clinical utility will improve the timely diagnosis, prediction of severity and will also aid in improving prognosis of DIC patients.
Authors and Affiliations
Nisal Amit| Department of Pathology, Bharati Vidyapeeth Deemed University Medical College, Pune, Corresponding author email: dramitnisal@yahoo.com, Nimbargi Ravindra| Department of Pathology, Bharati Vidyapeeth Deemed University Medical College, Pune, Shelke Parineeta| Department of Pathology, Bharati Vidyapeeth Deemed University Medical College, Pune, Kelkar Anjali| Department of Pathology, Bharati Vidyapeeth Deemed University Medical College, Pune
Keywords
Related Articles
- EP ID EP11439
- DOI 10.5958/2319-5886.2015.00105.8
- Views 312
- Downloads 11
LEARNING STYLES OF FIRST YEAR MEDICAL STUDENTS STUDYING PHYSIOLOGY IN TAMIL NADU
Background: Understanding the diversity of learning style preferences of first year medical students will help teachers of Physiology design teaching-learning activities that while catering to their preferences also ch...
A study of left ventricular dysfunction and hypertrophy by various diagnostic modalities in normotensive type 2 diabetes mellitus patients
The aim of this study was to assess the role of left ventricular dysfunction and hypertrophy by various diagnostic modalities in normotensive type 2 diabetes mellitus patients. The burden of cardiovascular disease relat...
EFFECT OF DIAPHRAGMATIC AND COSTAL MANIPULATION ON PULMONARY FUNCTION AND FUNCTIONAL CAPACITY IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE PATIENTS: RANDOMIZED CONTROLLED STUDY
Background: Many manual procedures have long been involved in the management of chronic obstructive pulmonary disease (COPD). Few literatures evaluated the COPD responses to individual or multiple manipulative techniq...
Prolongation of interpeak latency of brainstem auditory evoked potential in hypothyroidism
Hypothyroidism is a syndrome characterized by the clinical and biochemical manifestation of thyroid hormone deficiency. BAEPs are effective in evaluating the integrity of the peripheral and central auditory pathways. Th...
Comparison of the effectiveness of equal doses of short and long-acting erythrocyte stimulating agents for managing anemia in chronic kidney disease adult patients
Anemia is the most common side effect in patients with chronic kidney disease (CKD) mainly due to lower levels of erythropoietin (EPO) hormone. The aim of the present study is to compare the efficacy of equivalent doses...