Interstitial Cells of Cajal Pathology, injury and repair
Journal Title: Sultan Qaboos University Medical Journal - Year 2012, Vol 12, Issue 4
Abstract
Interstitial cells of cajal (ICC) are specialised cells located within the musculature of the gastrointestinal tract (GIT). Although they form only 5% of the cells in the musculature of the GIT, they play a critical role in regulating smooth muscle function and GIT motility in coordination with the enteric nervous system. C-kit is a transmembrane glycoprotein that plays a critical role in ICC development and maturation. Physiological conditions such as ageing, as well as pathological conditions that have different disease processes, negatively affect ICC networks and function. Absent or disordered ICC networks can be associated with disorders in GIT motility. Tis review highlights the mechanism of ICC recovery from various types of injury which entails understanding the development of ICC and the factors affecting it. ICC transformation into malignant tumours (gastrointestinal stromal tumours) and their potential as contributors to therapeutic resistance is also discussed.
Authors and Affiliations
Dhuha Al-Sajee| Department of Pathology & Molecular Medicine, Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, Ontario, Canada, Jan D. Huizinga| Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, Ontario, Canada
Epidemiology, Outcomes and Coronary Angiography Findings of Patients Following Out-of-Hospital Cardiac Arrest: A single-centre experience from Oman
Objectives: Out-of-hospital cardiac arrests (OHCAs) are a leading cause of death worldwide. However, data regarding the management and outcomes of affected patients are lacking in the Middle East. The current study aimed...
Knowledge and Attitudes Towards Basic Life Support Among Health Students at a Saudi Women’s University
Objectives: Awareness of basic life support (BLS) is paramount to ensure the provision of essential life-saving medical care in emergency situations. Tis study aimed to measure knowledge of BLS and attitudes towards BL...
“Different Strokes” A management dilemma
Stroke is a common medical emergency resulting from numerous pathophysiological mechanisms and with varied clinical manifestations; as such, the diagnosis of stroke requires diligent clinical assessment. When different...
Clinical Signifcance of an Unusual Variation Anomalous additional belly of the sternothyroid muscle
Te infrahyoid muscles are involved in vocalisation and swallowing; among these, the sternothyroid muscle is derived from the common primitive sheet. Te improper differentiation of this muscle may therefore result in m...
Nephropathic Cystinosis First reported case in Oman
Cystinosis is an autosomal recessive, lysosomal storage disease characterised by the accumulation of the amino acid cystine in different organs and tissues. It is a multisystemic disease that can present with renal and...