Intestinal microflora imbalance in liver cirrhosis - potential clinical and therapeutic implications
Journal Title: Gastroenterologia Polska - Year 2008, Vol 15, Issue 3
Abstract
The imbalance of intestinal microflora in patients with liver cirrhosis is common and plays an important role in the pathogenesis of life threatening complications. Hepatorenal syndrome is an example of serious complication of decompensated cirrhosis. lt occurs as a consequence of several pathologic activations of enzymatic pathways, which lead to serious but initially reversible hemodynamic disturbances. However, party due to our limited knowledge of its pathomechanism the pharmacological treatment is ineffective. The therapeutic substances with gut microbiota modifying properties might change the prognosis of patients with liver cirrhosis. Probiotics possess the potential to modulate synthesis of endogenous substances implicated in the pathogenesis of liver complications. In this paper we review the current knowledge on the role of intestinal microflora in liver cirrhosis and induction of its complications. Therapeutic and clinical implications with strong emphasis on probiotics in cirrhotic patients are discussed.
Authors and Affiliations
Wojciech Marlicz, Joanna Raszeja-Wyszomirska, Małgorzata Ławniczak, Piotr Milkiewicz
Keywords
Related Articles
- EP ID EP84187
- DOI -
- Views 103
- Downloads 0
Surgical treatment of ulcerative colitis
Authors present currently recommended methods of surgical treatment in patients with ulcerative colitis. Special stress is laid on proper choice of patients undergoing surgical treatment on either emergency or elective b...
Anorectal function in the irritable bowel syndrome depending on patients gender and age
Introduction: Urgency, excessive straining orfeeling of incomplete evacuation are the common complaints in patients with irritable bowel syndrome (IBS) that may suggest anorectal dysfunction and rectal hypersensitivity....
Sensitivity of genetic testing for Gilbert syndrome in Polish population
Introduction: Gilbert syndrome is recognized as mild unconjugated hyperbilirubinemia. It is associated with the A (TA)„TAA insertion polymor-phism in the promoter region of the gene coding for the enzyme UDP-glucuronosyl...
Contemporary opinions on diagnosis and treatment of anal abscesses and fistulas in the course of Crohn's disease
Fistulas and abscesses of the anuscaused by Crohn's disease (CD) constitute a therapeutic problem due to low effectiveness of conservative and surgical treatment as well as recurrent type of disease. Epidemiological data...
Ocena jakości życia u chorych z zaporową żółtaczką, bólem trzustkowym i powikłaniami ostrych rzutów zapalenia trzustki leczonych endoskopowo
Wprowadzenie: Szybki rozwój metod leczniczych zwiększył wachlarz wskazań do endoskopowej terapii chorób dotychczas zarezerwowanych dla leczenia chirurgicznego lub objawowego. Poziom jakości życia jest najlepszym wskaźnik...