Intraperitoneal Analgesia for Laparoscopic Cholecystectomy: Use of Bupivacaine with and Without Dexmedetomidine as Adjuvant
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2018, Vol 6, Issue 2
Abstract
Abstract: Intraperitoneal instillation of local anaesthetic agents alone or in combination with opioids, ∝‑2 agonists such as dexmedetomidine have been found to reduce post operative pain following laparoscopic cholecystectomy. The purpose of this study was to assess the analgesic effect of the intraperitoneal administration of intraperitoneal dexmedetomidine combined with bupivacaine and intraperitoneal bupivacaine alone in patients undergoing laparoscopic cholecystectomy. One hundred patients of (ASA) physical status I-II of both sexes, aged between 18 to 60 years, equally divided in to two groups, randomly allocated to one of the groups using table of randomization, Group B (n = 50): Intraperitoneal bupivacaine 30 ml 0.25% +5 ml normal saline (NS), Group BD (n = 50): Intraperitoneal bupivacaine 30 ml 0.25% + dexmedetomidine1u g/kg (diluted in 5 ml NS). Visual analogue scale was recorded half and hours, 1, 2, 4, 6 and 24 hours postoperatively. Incidence of postoperative nausea and vomiting (PONV) was also recorded. In addition, supplementary analgesic and antiemetic consumption were assessed. Statistical analysis was performed using Microsoft (MS) Office Excel Software with the Student’s t‑test and Chi‑square test (level of significance P = 0.05). Pain intensity, as well as postoperative supplementary medications were significantly lower in Group BD,(2.12±0.91) as compared to Group B( 4.21±1.15). Time to first request of analgesia (min) was longest (132±20),(60±19) and total analgesic consumption (mg) was lowest (48 ± 18), (182 ± 80) in Group BD than Group B. Intraperitoneal instillation of dexmedetomidine in combination with bupivacaine is an effective method for management of postoperative pain after laparoscopic cholecystectomy. It significantly reduced supplementary postoperative analgesic and antiemetic medication.
Authors and Affiliations
Dr. Mohamad Ommid, Ummer Ali, Shahzada Gani, Shaheeda Akhter, Nuzhat ul Islam, Saba Ahad, Anka Amin, Humera Manzoor
Keywords
Related Articles
- EP ID EP474121
- DOI -
- Views 125
- Downloads 0
Significance of Hyponatremia in Decompensated Chronic Liver Diseases
To assess the frequency of serum sodium and its correlation with the severity of chronic liver diseases. The Study Design is Prospective Study. The Place and Duration of Studyare Dr D Y Patil Hospital and Research Instit...
Comparative Study of Auditory and Visual Reaction Time in Patients of Type 2 Diabetes Mellitus on Allopathic Treatment and in Healthy Controls
Abstract: Diabetes is a worldwide epidemic also having high prevalence in Indian population. It leads to peripheral neuropathy affecting somatosensory and auditory system. It slows psychomotor responses, and has cognitiv...
Metabolic Alteration in Prostatic Neoplasm-An Eastern Indian Study
Prostate cancer, a disease of aging men, is a growing problem in Asian countries in last two decades. To find out any metabolic alterations in prostatic neoplasm. One hundred non diabetic men aged 50 to 80 yrs were selec...
A Study on various Clinical Presentations of Extradural Hemorrhage, Factors affecting Treatment and Early Outcome
Abstract:This study of 100 cases of extradural hemorrhage was performed at Mamata general & superspeciality hospital, Khammam during the period of Oct-2014 to Sep-2015. Road traffic accident was the commonest mode of inj...
Glioependymal Cyst of Filum Terminale-A Rare Case Report
Abstract: Filum terminale l cysts are rare, nonneoplastic intracranial cysts. Most of these are asymptomatic and present in the frontal and the parietal lobe. Conus medullaris and filum terminale are the rare sites for G...