Intrathecal midazolam for prevention of nausea and vomiting during and after cesarean section under spinal anaesthesia
Journal Title: Indian Journal of Clinical Anaesthesia - Year 2018, Vol 5, Issue 2
Abstract
Introduction Relevant incidences of nauseavomiting during and immediately after cesarean section in spinal anesthesia are found to be high Effectiveness of intrathecal midazolam 2 mg as an adjuvant to bupivacaine on the incidence and severity of intraoperative and immediate postoperative nausea and vomiting was investigated in the present studyMaterials and Methods A randomized controlled doubleblind study was conducted in 120 healthy women ASA Physical status I and II scheduled for elective cesarean section under spinal anesthesia Parturients were randomly divided into two equal groups of 60 each Group Mstudy group Patients received 10 mg 20ml of 05 hyperbaric bupivacaine combined with 2 mg 04 ml midazolam intrathecally and Group C control group 10 mg 20ml of 05 hyperbaric bupivacaine combined with 04 ml normal saline intrathecally Assessment of the patients were done for incidence of nauseavomiting hemodynamic effects and occurrence of adverse effects during cesarean section and during first 6 hours after the operationResults Incidence of emetic symptoms in Group M were significantly lower than Group C 15 vs 6334 p 0 There were no clinically serious adverse events observed in any of the groups All neonates had APGAR scores more than 8 at one and five minutesConclusion Intrathecal midazolam as an adjuvant to Bupivacaine is associated with lower incidence of nausea and vomiting with no neonatal adverse effectsKeywords Nausea Vomiting Intrathecal midazolam Spinal anesthesia Cesarean section
Authors and Affiliations
Amol Singam, Arpita Jaiswal, Rashmi Deshpande Tapan Dhumey
Keywords
Related Articles
- EP ID EP476455
- DOI 10.18231/2394-4994.2018.0042
- Views 101
- Downloads 0
Role of nitroglycerine as tocolytic agent during double valve replacement surgery in pregnant patient with successful fetal outcome
Cardiovascular disease is an important non-obstetric cause of maternal and fetal morbidity and mortality during pregnancy. Cardiac surgery during pregnancy is usually well tolerated by mother but the fetal outcome is var...
A comparative study of palonosetron and ondansetron in prevention of post operative nausea and vomiting in laparoscopic cholecystectomy surgery
Introduction: In this randomized, double-blind study we evaluated the relative efficacy of palonosetron (a new, selective 5hydroxytryptamine [5-HT3] receptor antagonist) and ondansetron in preventing postoperative nausea...
Low flow anaesthesia: economic, eco friendly and effective
Introduction: Low flow anaesthesia, a technique introduced by Foldes in 1952 has resurged in clinical practice due to easy availability of low solubility inhalational agents. Being economical, ecological and clinically a...
Spinal anaesthesia for caesarean section: Comparison of 25G Whitacre needles with 25G and 23G Quincke needles for technical problems and post-operative complications
Background: The well-known complication of spinal anaesthesia, postdural puncture headache (PDPH), is especially troublesome in young obstetric patients. The needle gauge and configuration of needle tip appear to be the...
Acute Fatty Liver of Pregnancy: Case series report
Acute fatty liver of pregnancy, a rare clinical entity demands early diagnosis, immediate delivery of fetus, systematic approach for correction of coagulopathy, renal injury & sepsis along with hemodynamic and ventilator...