INVESTIGATION OF ANTI-OBESITY ACTIVITY OF ETHANOLIC EXTRACT OF FOENICULUM VULGARE SEEDS, IN VIVO AND IN SILICO MODELS
Journal Title: WORLD JOURNAL PHARMACY AND PHARMACEUTICAL SCIENCE - Year 2019, Vol 8, Issue 11
Abstract
Background: Obesity is a chronic disease that triggers metabolic disorders due to excessive internal fat accumulation. Foeniculum vulgare (FV) is a very popular medicinal plant used to control obesity in the traditional medicine without any scientific evidence. Objectives: To evaluate the anti-obesity and anti-hyperlipidimic activity of ethanolic extract of Foeniculum vulgare seeds in vivo and identify the possible mechanism of action using molecular docking that is performed on plant constituent to target leptin receptor. Material and Methods: 16 albino rats were divided into four groups; group 1: none obese rats received (0.2 ml) normal saline daily, group 2: obesity control treated with modified High-fat hyper caloric diet, group 3: received plant extract (200 mg/kg) daily (I.P), and group 4: received Orlistat (2mg/kg) orally. Rats’ body weight and Lipid profile were assayed. For Molecular docking, ligands were obtained from previous studies, screening was performed using structure-based drug design against phytochemical constituent of Foeniculum vulgare, molecular modelling was done using Auto Dock Vina; only best conformers ligands with highest and best score was selected. Results: Reduction in rat’s body weights produced by Foeniculum vulgare ethanolic seed extract was12%, while Orlistat produced 6.4%. Triglycerides level wasn’t affected by treatment with plant extract and Orlistat. Molecular docking shows that Stigmast-5-en-3-ol have stronger binding at the leptin receptor’s binding site (-6.1 kcal/mol) when analyzed using AutoDockVina. Conclusion: Finally, this study concluded that Foeniculum vulgare ethanolic seeds extract demonstrate promising action as anti-obesity remedy since it shows a significant reduction in rat body weight and correct lipid profile, which provide scientific rationale for its folkloric use. Molecular docking suggests that the Stigmast-5-en-3-ol is a good candidate as leading compound for management of obesity disorders.
Authors and Affiliations
Dina A. Ghinmy
Keywords
Related Articles
- EP ID EP669815
- DOI -
- Views 153
- Downloads 0
BURDEN OF CEREBRAL MALARIA; PERSONALIZED MEDICINE TO THE RESCUE: A REVIEW OF THE NEW CONCEPT
Malaria is endemic in over 100 countries and about 240 million people are at risk of developing the disease. Annually, about 20-30 million clinical malaria cases occur globally with over 1 million deaths. In 2017 alone,...
SPECTROPHOTOMETRIC OXIDATION METHOD FOR THE DETERMINATION OF TAMSULOSIN IN THE PRESENCE OF DUTASTERIDE BY USING BROMATE – BROMIDE MIXTURE
A sensitive, precise, accurate, simple and rapid spectrophotometric method has been developed for the estimation of Tamsulosin in the presence of Dutasteride in pharmaceutical formulations and in the drug dosage form. Du...
A REVIEW ON PRESCRIPTON AFTER MYOCARDIAL INFARCTION, DOSAGE AND PERSISTENCE
Myocardial infarction is one of the most common forms of CAD. The morbidity and mortality rate is very high due to MI. Beta-blockers, angiotensin-converting enzyme (ACE)-inhibitors and statins are widely recommended for...
EFFICACY OF TYLOSIN AND SALINOMYCIN ON SOME GROWTH PARAMETERS IN BROILER CHICKENS CHALLENGED WITH CLOSTRIDIUM PERFRINGENS
This study was carried out to investigate the effects of tylosin (100 ppm) and salinomycin (60 ppm) and their combination in feed on some growth parameters in broilers chickens challenged with Clostridium perfringens whi...
ROLE OF DRUG REGULATORY AFFAIRS IN PHARMA INDUSTRY
Drug Regulatory Affairs (DRA) is a vital unit in a pharmaceutical company as it is concern about the healthcare of people and shelf life of product. it provide planned, premeditated and prepared direction and support for...