Investigation of Leptin, Leukemia Inhibitory Factor (LIF), and IL-6 Serum Levels in Myeloid Leukemia
Journal Title: Iranian Journal of Blood and Cancer - Year 2010, Vol 2, Issue 4
Abstract
Background: Leptin has been implicated in the differentiation and proliferation of hematopoietic cells. Leukemia inhibitory factor (LIF) may play an important role, along with Interleukin-6 (IL-6) and granulocyte colony stimulating factor (G- CSF), in the regulation of early hematopoietic stem cells. The aim of the study was to evaluate serum level of leptin, LIF, and IL-6 in myeloid leukemia patients. Materials and Methods: We investigated serum level of leptin, LIF, and IL-6 levels, body mass index, hemoglobin, and hematocrit in 30 myeloid leukemia patients (15 patients with acute and 15 with chronic myeloid leukemia) before chemotherapy, and compared the results with 15 healthy controls. Results: Leptin, LIF and IL-6 serum levels, and lipid profile in myeloied leukemic patient was significantly different from the control group (p<0.05). The relationship between leptin and BMI was statistically significant in control group, whereas in the patient group, there were no significant relationship between leptin and BMI. Conclusion: Lipid profile and leptin, LIF, and IL-6 serum levels of leukemic patients were significantly different from normal population.
Authors and Affiliations
Shaban Alizadeh, Shahab Bohloli, Ali Abedi, Seyed Hadi Mousavi, Hossein Dargahi, Behzad Jafarzadeh, Nourooz Hamrang
Keywords
Related Articles
- EP ID EP376978
- DOI -
- Views 83
- Downloads 0
Evaluation of the Relationship Between Factor IX Inhibitor in Hemophilia B Patients and Different Types of Therapy in the North-eastern Part of Iran
Background: Hemophilia B is a bleeding disorder with a recessive X-linked inheritance pattern, in which the infected individuals have low levels of factor IX in their plasma. Affected individuals may have bleeding episod...
Leukemia Cutis in a Child with Acute Lymphoblastic Leukemia at Diagnosis and Relapse
This article has no abstract.
Treatment of Newly Diagnosed and Relapsed Hodgkin Lymphoma in Children
Hodgkin lymphoma (HL) accounts for about 10% of all childhood cancers. Five-year survival rates with modern therapies are now approaching >90-95% as a consequence of its significant sensitivity to both chemotherapy and r...
Very late recurrence of gastric cancer with bone mar-row anemia as a stem cell disease: a lesson for future
This article has no abstract.
Quality Assurance and Good Manufacturing Practice in Respect of Plasma Fractionation
The Quality centers shall build up a quality system. This comprises all activi-ties in the blood center intended to ensure that all blood and all components have a quality corresponding to the intended use. Quality Assu...