Investigation of Mean Platelet Volume, Platelet Distribution Width and Erythrocyte Distribution Width in Patients with Hepatitis B Virus Infection
Journal Title: Viral Hepatitis Journal - Year 2017, Vol 23, Issue 2
Abstract
Objective: Hepatitis B virus (HBV) infection is an important public health issue all over the world, and it has a high morbidity and mortality rates caused by chronic liver disease. Liver biopsy is the primary procedure for evaluating the fibrosis grade. Recently, non-invasive methods are used to predict liver histology. Complete blood count (CBC) is one of the most needed and used laboratory tests in clinics. CBC parameters have been used in various studies to estimate the severity of the disease and the risk of mortality. In the present study, we aimed to determine the relationship of HBV infection with mean platelet volume (MPV), platelet distribution width (PDW) and red cell distribution width (RDW). Materials and Methods: Two hundred fifty-nine hepatitis B surface antigen (HBsAg)-positive patients, who attended the Infectious Diseases outpatient Clinic at Van Military Hospital between October 2013 and December 2014, were included in the study group. A total of 245 food handlers with similar socio-demographic characteristics with the study group, who applied at the same period, formed the control group. HBsAg-positive patients were studied in two groups as chronic active hepatitis and inactive carriers according to their follow-up. CBC results of the patients and the healthy controls were screened from the hospital information system and they were evaluated retrospectively. Results: The average platelet count in HBsAg-positive patients and controls was 262.59±62.13x103/mm3 and 245.28±60.78x103/mm3, respectively and the difference between the groups was statistically significant (p=0.002). There was also statistically significant difference in RDW values between the two groups. The average RDW was 12.14±1.05 in HBV group, while it was 12.49±1.28 in control group (p=0.001). On the other hand, no significant difference was observed in PDW and MPV between the groups. Conclusion: It is thought that simple, inexpensive and routinely used platelet and erythrocyte parameters in combination with other inflammatory parameters may help predict liver inflammation. While platelets and RDW are decreased in people with HBV infection, MPV and PDW are not changed. We assume that platelets and RDW should be evaluated together in HBsAg-positive patients, and further studies with larger samples should be performed.
Authors and Affiliations
Kazım KIRATLI, Erdem ÇEVİK
Keywords
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- EP ID EP251838
- DOI 10.4274/vhd.62534
- Views 60
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