Investigation of phytochemicals and anti-diarrhoeal potential of an ignored grassCyperus esculentus L. root
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2014, Vol 2, Issue 3
Abstract
Diarrhoea is a condition that involves the frequent passing of loose or watery stools. According to the WHO, approximately 3.5 million deaths each year are attributable to diarrhoea. Medicinal plants have been used as traditional remedy for diarrhoea for years long and there is renewed interest in the discovery of novel compounds from plant to fight against diarrhoea. WHO also encourage studies on diarrhea which include research on traditional herbs. The present study was designed to investigate the antidiarrhoeal potential of 70% hydro-ethanolic extract of Cyperus Esculentus root on castor oil-induced diarrhoea in Wister rats. Phytochemical screening of the plant extract for their active constituents was also carried out using standard procedures. Oral administration of hydro-ethanolic extract of Cyperus esculentus (200 and 400 mg/kg) significantly, and dose-dependently delayed the onset of diarrhoea induced by castor oil and also significantly reduced the number of diarrhoeal episodes and the number of animals exhibiting diarrhoea. The results were comparable with standard synthetic antidiarrhoeal drug, loperamide. Phytochemical screening also revealed the presence of alkaloids, tannins, flavonoids and carbohydrates, as major constituents. The results point out the presence of some active principles in Cyperus esculentus root extract possessing a promising anti-diarrhoeal effect and substantiate the use of this herb as a nonspecific treatment for diarrhoea in folk medicine.
Authors and Affiliations
Pulak Majumder
Keywords
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