Investigation of The Relationship Between Congenital Hypothyroidism and Respiratory Distress Syndrome in Very Low Birth Weight Newborns
Journal Title: Journal of Ankara University Faculty of Medicine - Year 2019, Vol 72, Issue 3
Abstract
Objectives: Respiratory distress syndrome (RDS) is associated with severe morbidity and mortality, which occurs due to surfactant deficiency in the lung. In the present study, we aimed to determine the risk factors for RDS and the effect of congenital hypothyroidism (CH) on RDS in very low birth weight (VLBW<1500 g) infants. Materials and Methods: The study was completed between January 2013 and August 2017. Data of eligible infants were obtained from hospital medical records. Patients were divided in to groups with and without CH, and those with and without RDS according to requirement of surfactant therapy. Results: Six hundred and seventy patients of 729 patients (gestational age: 27.5±1.3 weeks, birth weight: 1014±219 g) were included in the study, and thyroid function test results were obtained on day 5th respiratory distress syndrome ratio was 71.4% (n=20) in the CH group (n=28) and 61.3% (n=394) in the non-CH group (n=642). Respiratory distress syndrome ratio (71.4%) was found to be statistically higher in CH group than those in non-CH group (61.3%) (p=0.000). The frequency of CH (5.3% vs 2.3%, p=0.015, respectively) was higher in patients with RDS. RDS ratio in those with CH and CHD in those with RDS were found to be higher. Conclusion: Based on these findings, it is thought that thyroid hormones may affect lung development and dynamics.
Authors and Affiliations
Ufuk Çakır, Cüneyt Tayman, Buse Özer Bekmez, Mehmet Büyüktiryaki, Erbu Yarcı
Keywords
Related Articles
- EP ID EP684789
- DOI 10.4274/atfm.galenos.2019.49469
- Views 141
- Downloads 0
Penetran Tracheal Injury: A Rakshe Accident
Tracheal injury is a rare pathology, but 30% of all cases can be fatal and 50% of those patients will deteriorate in couple of hours and may lead to death. The course of treatment must be scheduled by clinical status and...
Short-term Results of Total Hip Arthroplasty Cases with Osteonecrosis of the Hip
Objectives: Avascular necrosis (AVN) of the femoral head is a type of osteonecrosis caused by impaired blood flow to the proximal femur. Femoral head collapse and coxarthrosis are seen in more than 30% of the patients wi...
Factors Affecting Prognosis in Hypoxic Encephalopathy Patients Followed-up in Intensive Care Unit
Objectives: Hypoxic encephalopathy (HE) after cardiac arrest is a clinical condition that can cause severe neurological sequelae and death. It is important to determine the prognosis in patients with HE for follow up and...
Reversible Nephrotoxicity of Colistin: A Case Report
Both nosocomial and community acquired gram-negative bacterial infections cause serious morbidity and mortality. However, old antibiotics, which have toxic side effects, should be re-used because of the lack of newly dev...
Evaluation of the Reliabilty of Endoscopic Examination For Determining Gastritis
Objectives: This study was planned for evaluating the reliability of endoscopic examination findings in patients with dyspepsia. It can also be considered as a pilot study for broader, population studies. Materials and...