INVESTIGATION ON DISSOLUTION PATTERN AND MATHEMATICAL MODELING OF DRUG RELEASE OF QUERCETIN BY COMPLEXATION WITH CYCLODEXTRIN NANOSPONGES
Journal Title: Asian Journal of Pharamceutical and Clinical Research - Year 2019, Vol 12, Issue 5
Abstract
Objective: The main objective of this study was to investigate the release pattern of a poorly water-soluble drug quercetin (QU) by fabricating its cyclodextrin nanosponges. Methods: Characterization of the original QU powder and QU-loaded nanosponges was carried out by the Fourier-transformed infrared (FTIR) spectroscopy, transmission electron microscopy (TEM), and dissolution tester. The drug release pattern was subjected to various kinetic models. Results: FTIR studies confirmed the formation of inclusion complex of drug. The particle size analysis revealed that the average particle size measured by laser light scattering method is around 400–420 nm with low polydispersity index. The particle size distribution is unimodal and having a narrow range. A sufficiently high zeta potential indicates that the complexes would be stable and the tendency to agglomerate would be miniscule. TEM image revealed the porous nature of nanosponges. The dissolution of the QU nanosponges was significantly higher compared with the pure drug. Conclusion: From the kinetic study, it is apparent that the regression coefficient value closer to unity in case of Korsmeyer-Peppas model indicates that the drug release exponentially to the elapsed time. n value obtained from the Korsmeyer-Peppas plots, i.e., 0.9911 indicating non-Fickian (anomalous) transport ; thus, it projected that delivered its active ingredient by coupled diffusion and erosion.
Authors and Affiliations
SOBITHARANI P , ANANDAM S , MOHAN VARMA M , VIJAYA RATNA J , SHAILAJA P
Keywords
Related Articles
- EP ID EP604752
- DOI -
- Views 122
- Downloads 0
ANTIDERMATOPHYTIC ACTIVITY OF ANGIOSPERMIC PLANTS: A REVIEW
In recent years, there has been increasing interest worldwide in the use of alternative/herbal medicine for the prevention and treatment of fungaldiseases. Currently, however, quality-related problems (lack of consistenc...
ASSESSMENT OF SMOKING BEHAVIOR AMONG MALAY MALE SMOKERS IN KELANTAN, MALAYSIA
Objective: The aim of this study was to assess smoking behavior among Malay male smokers in Kelantan, Malaysia.Methods: Volunteers (n=496) were recruited in the study by randomly selected manner. The participants were ca...
DEVELOPMENT AND VALIDATION OF HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY WITH DIODE ARRAY DETECTOR METHOD TO ANALYSIS OF KAEMPFEROL MARKER FROM EXTRACTS OF POINCIANELLA PYRAMIDALIS (TUL) L.P QUEIROZ
Objective: This study aims to develop the extraction of the marker kaempferol in the fluid extract (FE) and validate an analytical method that monitors the quality of extracts of P. pyramidalis. Methods: The P. pyramidal...
STOOL FORM SCALE AS AN INDICATOR OF KLUTUK BANANA (MUSA BALBISIANA COLLA) FRUIT EXTRACTS INHIBITION EFFECT AGAINST SHIGELLA DYSENTERIAE ATCC 13313 IN VIVO
  Objective: Stools consistency is a common symptom indicating in dysenteriae. The aim of this study was to investigate the inhibitory effect of the klutuk banana fruit extract that determine different degrees of stool...
AMELIORATIVE EFFECT OF BAUHINIA VARIEGATA ON HYPERCHOLESTEROLEMIA-INDUCED OXIDATIVE STRESS IN RATS
Objective: The objective of this study was to assess the effect of the methanolic extract of Bauhinia variegata (L.) stem bark in albino rats. Methods: The coarsely powdered stem bark of B. variegata (L.) was extracted...