INVESTIGATION ON THE HYPOGLYCEMIANT EFFECT OF SOME VEGETAL EXTRACTS IN EXPERIMENTAL INTOXICATIONS AT CD-1 MICE
Journal Title: Current Trends in Natural Sciences - Year 2016, Vol 5, Issue 10
Abstract
Using plants in treating some diseases has become a tradition, ‘the nature’s pharmacy’ being an important source of therapy. At present, the medicinal plants properties are being re-assessed due to progress made in chemical, pharmaceutical and clinical research of plants and due to forms obtained from vegetal products, but especially due to the advantages they offer. In the context of more frequent use of natural products with pharmaceutical and therapeutical aims, both at a national and at an international level, our research hints at highlighting and giving details about a series of effects produced by vegetal extracts of Aronia melanocarpa and Silybum marianum on certain physiological, biochemical and histopathological processes at CD1 mice. In this study, 2 hydro-alcoholic extracts obtained from 2 species of medicinal plants (Aronia melanocarpa and Silybum marianum), were tested in order to analyse the hypoglycemiant activity. The data accumulated in the specialty literature reveal that the phytotherapeutic use of extracts of Aronia melanocarpa and Silybum marianum is based only on the major pharmacologic effect while the intimate action mechanism of the two vegetal products, al cellular and subcellular level, is not known. Starting from these premises, we considered useful the initiation of a comparative study regarding the antidiabetic influence of fluid extracts of Aronia melanocarpa and Silybum marianum upon mice experimentally intoxicated with alloxan monohydrate solution. CDI mice were used as an experimental model in order to induce diabetes: alloxan monohydrate was injected intraperitoneal with concentration of 130 mg/kg body (Ahmed Saber Abu – zaiton, 2013), dissolved in physiological serum, during two weeks, at an interval of 3 days. Both extracts acted positively by lowering blood sugar and by returning to normal body weight in diabetic mice. Aronia extract has a pronounced effect compared to milk thistle extract for both parameters monitored in the experiments.
Authors and Affiliations
Monica Bucă, Magdalena Cristina Zagardan, Mădălina Elena Scarlat, Alina Păunescu, Cristina Maria Ponepal, Alexandru Gabriel Marinescu
Keywords
Related Articles
- EP ID EP25087
- DOI -
- Views 320
- Downloads 10
MYCELIAL BIOMASS PRODUCTION OF THE SUN MUSHROOM (AGARICUS BLAZEI MURRILL)
Agaricus blazei Murrill has indeed generated a lot of interest in the scientific community. One of the components of mushroom was a polysaccharide complex with a low molecular weight called α-1.4-Glucan, β-1.6-Glucan. T...
THE ANSERIFORMES FROM THE BASINS OF THE ARGEŞ RIVER BETWEEN VÂLCELE AND GOLEŞTI (ARGEŞ COUNTY, ROMANIA) IN FEBRUARY 2013 – JANUARY 2014
In this paper, the authors show the results of their research on the species of Anseriformes, performed on the dam lakes between Vâlcele and Goleşti from the Argeş River during February 2013 – January 2014. The Anserifo...
ORNITHOLOGICAL RESEARCHES ON THE PITEŞTI BASIN DURING 2003 – 2011
In this paper the authors show some ecological researches about the ornithofauna registered on the Piteşti Basin (part of the Argeş River Basins, site included in the Nature 2000 network) performed during 2003 – 2011. 1...
EX VITRO STUDY ON TESTING THE TREATMENT WITH A STIMULATING EFFECT ON THE SEED GERMINATION RATE OF OCIMUM BASILICUM L.
The stimulation of the seed germination rate may be one of the ways to prevent environmental attacks of byotik or abyotik agents on the quality of seedlings. One of the factors involved in stimulating the germination ra...
STRESS RESPONSE TO NICKEL IN ASPLENIUM SCOLOPENDRIUM L. AND DRYOPTERIS FILIX-MAS (L.) SCHOTT.
The aim of this study was to determine the physiological response and the defensive potential in species Asplenium scolopendrium L. and Dryopteris filix-mas (L.) Schott under the action of nickel. The following experime...