Iron and Copper Toxicity in Rat Liver: A Kinetic and Holistic Overview
Journal Title: Liver Research – Open Journal - Year 2017, Vol 2, Issue 1
Abstract
Iron (Fe) and copper (Cu) overloads in rats showed a dose and time dependent metal accumulation in liver with its associated toxicity. The increased contents of the transition metals markedly enhanced the endogenous free-radical mediated processes of phospholipid peroxidation. In vivo liver chemiluminescence showed an increased production of 1 O2 , and a consumption of reduced glutathione (GSH), the main intracellular antioxidant. Results fit with a Haber-Weiss type molecular mechanism in which Fe or Cu and endogenously produced O2 - and H2 O2 , yield HO• that initiates free-radical mediated phospholipid peroxidation and protein oxidation.
Authors and Affiliations
Marisa G. Repetto
Keywords
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- EP ID EP556362
- DOI 10.17140/LROJ-2-110
- Views 165
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