Is There a Correlation Between DAS28/RADAI in a Cohort of Rheumatoid Arthritis Patients Treated with Biological Therapy
Journal Title: Journal of Rheumatic Diseases and Treatment - Year 2016, Vol 3, Issue 1
Abstract
Aim: To describe the degree of activity of RA patients receiving biological agents co-monitored by rheumatologist and nurses. To assess RA activity using validated methods: DAS28, RADAI, visual analog scales (VAS), and to evaluate the correlation between them and the applicability in routine clinical practice. Methods: 114 patients with RA treated with biological agents, according to the American College of Rheumatology (ACR) 2010 criteria in shared nursing consultations from 12 Catalan hospitals were included. We analyzed whether there was good correlation between RADAI index and DAS28. Results: The mean value in the VAS scale was 2.85 (SD = 2.15), the mean RADAI self-assessment questionnaire level was 2.74 and the mean DAS28 index was 2.89. The majority of patients (63.1%) had a low disease activity (DAS28 < 3.2). 49/114 patients (44.1%) had a DAS < 2.6 (remission). Most patients treated with biologic agents have a good control of the disease, as measured by DAS28 objectively and subjectively by RADAI. Conclusions: The involvement of a multidisciplinary team (rheumatologist/ nursing) can coordinate patient care and establish consensus on the management of RA patients. Even though there are different tools of establishing the status of our patients, metrological evaluation with DAS28 is to date the most reliable, flexible and reproducible outcome measure.
Glucocorticoid-Induced Leucine Zipper (Gilz) in Rheumatoid Arthritis: Relationship with Disease Activity and Steroid Use
Aims: Approximately 50% of rheumatoid arthritis (RA) patients require treatment with glucocorticoids (GC) to control inflammation [1]. Although effective, GC cause numerous adverse effects. Glucocorticoid-induced leucine...
Rheumatoid Pulmonary Nodules and Significantly Elevated Urinary Cadmium in a Kaolin (China Clay) Worker: Could Cadmium Adsorption onto Occupationally Inhaled Dust Explain Caplan's Syndrome?
Introduction Over 60 years ago Caplan's syndrome was described in the coal miners of South Wales (UK). Higher rates are seen in mining populations globally, particularly in kaolin workers. We describe Caplan's syndrome i...
Rheumatoid Arthritis of the Craniovertebral Junction: Surgical Strategies, Current Approach and Proposal of a New Therapeutic Algorithm
Rheumatoid Arthritis (RA) is a systemic inflammatory disease with an autoimmune feature and an etiology that is still unknown. It is characterized by a symmetrical peripheral polyarthritis that affects primarily the smal...
TB: Falsely Accused? (A Case Report and Discussion)
Interferon-Gamma Release Assays (IGRAs) in the past decade have become ubiquitous screening for tuberculosis (TB). Development of these interferon release tests helped screen for TB in patients at high risk, specifically...
SLE - Update Ethiopathogenesis Leading to Biological Therapy
Systemic lupus erythematosus is a chronic, autoimmune disorder which may have even fatal consequences, particularly if it affects vital organs of the human body. It is typically manifested by inflammation of various orga...