JAK2 V617F Mutation in a Patient With Adrenal Incidentaloma and Essential Thrombocythemia
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2014, Vol 2, Issue 6
Abstract
A 62-year-old woman is incidentally found to have adrenal mass, 24*15 mm in diameter, on abdominal computed tomography for evaluation of acute arterial occlusion. Biochemical screening was negative for a functioning adrenal tumor. Routine blood works were significant for a platelet count of 572.000/mm3. Platelet counts were measured again and it’s found as 1.080.000/ mm3. The JAK2 V617F mutation was positive which investigated for the etiology of thrombocytosis. Inappropriate JAK2 signaling causes the survival of some solid tumors and cell proliferation. Our case is the third coexistence of the JAK2 V617F mutation with essential thrombocytosis and non-functional adrenal incidentaloma. Keywords: JAK2 V617F Mutation; Adrenal Incidentaloma; Essential Thrombocythemia.
Authors and Affiliations
Ferhat Ekinci, Utku Erdem Soyaltın, Tuba Demirci Yıldırım, Hamiyet Yılmaz Yaşar, Harun Akar
Keywords
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