JOBELYN ATTENUATES NEURONAL DEGENERATION IN CEREBELLAR CORTEX OF ADOLESCENT RAT EXPOSED TO BINGE ALCOHOL
Journal Title: European Journal of Biomedical and Pharmaceutical Sciences - Year 2018, Vol 5, Issue 2
Abstract
Cerebellar neurodegeneration is associated with chronic alcohol abuse. There is no clinically potent drug for alcohol-induced neurodegeneration. Though, it was hypothesised that multimodal neuroprotective agent presented outstanding therapeutic potentials in the management of CNS degeneration, however, the knowledge of what could constitute an effective and safe multimodal agent is not clear-cut. However, medicinal botanicals are naturally multimodal in their mechanism of action. The objective of this study is to assess the effect of Jobelyn supplement in a binge alcohol-induced neurodegeneration of the cerebellar cortex in adolescent rats. Two groups of adolescent rats were binge fed with either alcohol (25% w/v) or alcohol (25% w/v) and Jobelyn supplement in diluted nutritionally complete diet, 8 hourly for four consecutive days. The control animals received isocaloric non-alcoholic diet for equivalent days. The cerebellar cortices of animals in each group were evaluated histopathologically for degenerative changes. The extent of oxidative damage in the cerebellar cortex was assessed by tissue malondialdehyde (MDA), and advanced oxidation protein products (AOPP), concentrations. Results indicated that repetitive ethanol intoxication caused neuronal degeneration and oxidative damage in the cerebellar cortex. Jobelyn supplementation in alcohol-exposed rat significantly lowered the extent of neurodegeneration and oxidative damage. It was opined that the neuroprotective action of Jobelyn in alcohol-induced cerebellar neurodegeneration in adolescent rats is possibly through reductions of oxidative stress and neuronal degeneration.
Authors and Affiliations
Dr. Robert F. O.
Keywords
Related Articles
- EP ID EP635505
- DOI -
- Views 155
- Downloads 0
STUDY ON THE UTILIZATION OF ALUM AND MORINGA OLEIFERA IN WASTE WATER TREATMENT
The utilization of Alum and Moringa oleifera in the treatment of waste water was study comparing between the Moringa oleifera (MO) and Alum was conducted to obtain an insight into the various bacteria associated with was...
PARKINSON'S DISEASE, EXERCISE THERAPY AND ACTIVITY OF DAILY LIVING
Parkinson's disease (PD) is a progressive neurological disease with tremor, bradykinesia, akinesia and rigidity. These symptoms significantly hamper the performance of activities of daily living (ADL), which are necessar...
TRANSDERMAL PATCHES: PRINCIPLES, EVALUATION AND PERSPECTIVES
The skin is considered to be one of the most accessible and convenient site for the administration of various medications. Transdermal drug delivery systems are formulated with the intent of developing safe and efficacio...
INVENTORY OF NECROPHAGOUS INSECTS INVOLVED IN THE DECOMPOSITION PROCESS OF A PIG CORPSE (SUS SCROFA DOMESTICUS L.) EXPOSED TO THE OPEN AIR IN THE SOUTHERN FOREST ZONE OF CÔTE D'IVOIRE
In Côte d'Ivoire, necrophagous insects have since 2008, begun to arouse a keen interest among researchers. After the first works by Adou (2014), on the anthropological aspects, of the colonization of a monkey corpse by i...
ASSOCIATION OF HELICOBACTER PYLORI INFECTION AND VITAMIN B12 LEVEL AMONG SUDANESE PATIENTS IN KHARTOUM STATE-2018
Helicobacter pylori is an organism that is reported to cause deficiency of vitamin B12 by producing gastritis and peptic disease which results in vitamin B12 malabsorption, the exact mechanism is unknown but the suggeste...