Karyotypic Study Of Chronic And Blastic Phase Chronic Myeloid Leukemia Patients of Gujarat State
Journal Title: National Journal of Integrated Research in Medicine - Year 2010, Vol 1, Issue 1
Abstract
For present work, 27 clinically diagnosed Chronic Myeloid Leukemia patients were selected, who attended the Out Patient Department of Gujarat Cancer and Research Institute, Ahmedabad. In all these cases relevant history, clinical findings, haematological data and other investigations were noted & bone-marrow samples were obtained for further study, which was done at Genetics Laboratory, B.J. Medical College, Ahmedabad. Samples were cultured, harvested, slides were prepared & photographs were obtained using photomicroscope and Karyotypes were prepared by using conventional cut and paste technique. Cytogenetic evaluation was done to detect the presence of Philadelphia chromosome and/or other chromosomal abnormalities. Out of 27 patients studied, 22 cases were having mild to moderate & remaining 5 cases were having huge splenomegaly. The blood picture showed, 9 were anaemic; 11 having total leukocytic count more than 1 lakh/mm3 ; 8 cases were thrombocytopenic. 25 cases were in chronic and 2 cases were in blastic phase. Cytogenetic evaluation by Karyotypes revealed 13 Ph’ positive cases; 4 Ph’ negative; 3 mosaic & remaining 7 cases came out inconclusive. All relevant parameters including clinical, hematological and cytogenetic were evaluated, analyzed and compared with other similar studies.
Authors and Affiliations
Dr. V. B. Kariya, Dr. D. J. Trivedi, Dr. P. S. Srimankar, Dr. C. A. Pensi, Dr. D. V. Thakker
Keywords
Related Articles
- EP ID EP40088
- DOI -
- Views 403
- Downloads 0
Arthroscopic Treatment of Popliteal Cyst and Visualization of Its Cavity Through the Posterior Portal of the Knee
In regard to arthroscopic treatment of popliteal cysts, we explored the refuted pathology for popliteal cysts proposed by others. Here we introduce an arthroscopic technique using posterior portals to treat a popliteal...
A Study Of Palmar Dermatoglyphics In Leprosy in Bhavnagar District
Dermatoglyphics, the ridged skin covering our palms and sole, are not only found on human beings. All primates have ridged skin, and it can also be found on the paws of certain mammals and on the tails of some monkey s...
Measurement of Ulnar Length for estimation of Stature in Gujarat
In this study, an attempt has been made out to formulate a linear regression equation for estimation of stature from the ulnar length. The material consists of 310 subjects between 20-40 years of age in Gujarat. The Ul...
High Risk Factors for Elevated Excretion of Albumin In Diabetic Subjects
Background: Microalbuminuria refers to the excretion of albumin in the urine at a rate that exceeds normal limits but is less than the detection level for traditional dipstick methods and is considered as a marker of d...
Effect Of Celery (Apium Graveolens) Seeds Extract On Protease Inhibitor (Ritonavir) Induced Dyslipidemia
Objective: The present study was carried out to explore protective effects of ethanolic extract of Apium graveolens (celery seeds) on ritonavir, a protease inhibitor induced dyslipidemia. Materials & Methods: Thirty mi...