Ki67 immunoexpression in ovarian tumours
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 17, Issue 2
Abstract
Background: Mitotic count is a traditional and practical important method to determine proliferative activity. Immunohistochemical detection of proliferative cells is a alternative way to determine the proliferative potential of tumour, and the expression of Ki67antigen has a widely used marker.Ki67 is a nuclear protein expressed in cells during the active phase of the cellular cycle(G1, S, G2& M) and absent in G0 phase. The determination of growth fraction using Ki67 is a simple method and has been shown to have a prognostic value in a variety of malignancies. Material and methods : - The present study “Ki67 immunoexpression in ovarian tumours “ was carried out in the Department of Obstetrics and Gynaecology in collaboration with the department of Pathology , RIMS, Ranchi, in the period between May 2013 to October 2014. Sample size were 100. Results: mean Ki67 index of benign ovarian tumours is 3.7±2.64%, malignant ovarian tumours is 40.15±9.3%, borderline ovarian tumours is 17±2.83%. statistical difference observed between benign, borderline, malignant ovarian tumours while no statistical difference found between different histological types of ovarian tumours. Conclusion: In the present study,high Ki67 index observed in malignant ovarian tumours hence suggest the aggressive behaviour of the tumour and poor clinical outcomes.
Authors and Affiliations
Dr Kumudini Sardar, Dr Jitendra Singh2, ,Dr Sarita Tirkey3
Keywords
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- EP ID EP365853
- DOI 10.9790/0853-1702163437
- Views 82
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