Kigelia africana Stem Bark, Fruit and Leaf Extracts Alleviate Benzene-induced Leukaemia in Rats
Journal Title: Journal of Pharmaceutical Research International - Year 2017, Vol 18, Issue 2
Abstract
Aims: This study was aimed at evaluating the potential leukaemia chemotherapeutic activities of various extracts of Kigelia africana stem bark; fruit and leaf by using a benzene-induced model of leukaemia to validate its folkloric use. Evidences from African herbal medicine and traditional applications have shown that Kigelia africana plant has several beneficial therapeutic properties against microbial infections and cancer cell lines. Study Design: Experimental study. Place and Duration of Study: Department of Biomedical Science, College of Health Sciences, Ladoke Akintola University of Technology, Osogbo, Nigeria and study was conducted between August, 2016 and November, 2016. Methodology: Rats were administered 0.2 mL of benzene solution intravenously through the tail 48-hourly for 4 weeks, tested periodically and observed till leukaemia developed prior to treatment with respective extract of the Kigelia africana stem bark, fruit and leaf in appropriate rat groups after leukaemia was confirmed with haematological protocols. Leukaemic rats were administered with 100 mg/mL contained in 0.5 mL stem bark, 0.5 mL fruit and 0.2 mL of the leaf extract orally by gavage using oral cannula once daily post leukemia induction for four weeks. Haematological parameters and white blood cells differential counts (lymphocytes) were assessed in both control and treatment groups to determine the leukaemia burden. Results: Kigelia africana treatment using the stem bark, fruit and leaf significantly (P < 0.05) alleviated the anaemia indices and reduced the marked leucocytosis usually associated with leukaemia toward the negative control level when compared with the leukaemia control group. Antileukaemic activity however appears to be highest in stem bark, and least in the leaf. Conclusion: This study revealed the potential of ethanol extracts of Kigelia africana stem bark, fruit and leaf to reverse leukaemic effects in benzene-induced leukaemia bearing wistar rats and this suggest that the extracts might be promising natural, non-toxic and anticancer agents.
Authors and Affiliations
Akanni E. Olufemi, Olaniran I. Omotayo, Akinbo B. David, Iyiola Monjeed, Ogunlade Adebola, Sanni Bilikis, Adejumo Temitope
Keywords
Related Articles
- EP ID EP312906
- DOI 10.9734/JPRI/2017/34625
- Views 144
- Downloads 0
Chitosan Nanoparticles for Topical Co-administration of the Antioxidants Glutathione and Idebenone: Characterization and In vitro Release
Aims: The aim of this study was to explore the potential of novel nanoparticles (NPs) intended for topical administration of the hydrophilic antioxidant Glutathione and the lipophilic Idebenone. Glutathione was introduce...
Anti-oxidant and Anti-inflammatory Activity of Cassia auriculata (Flowers)
Aim: To analyze the antioxidants and anti-inflammatory potential of ethanolic crude extract of Cassia auriculata flowers. Study Design: 2 kg of fresh flowers were soaked with 90% ethanol at room temperature (25ºC-30ºC)....
Mucoadhesive Potentials of a Natural Polymer Obtained from the Seeds of Dioclea reflexa in Aminophylline Tablet Formulations
Aim: The mucoadhesive potentials of a natural gummy polysaccharide obtained from the seeds of Dioclea reflexa Hook F., (Fam.: Papilionaceae) (DR) was evaluated under varying pH conditions using aminophylline tablet formu...
Evaluation of Antioxidant Activity of Giant African Snail (Achachatina maginata) Haemolymph in CCl4- Induced Hepatotoxixity in Albino Rats
Objective: To evaluate the acute toxicity, in vitro antioxidant and hepatoprotective activities of Giant African Snail (Achachatina maginata) haemolymph against carbon tetrachloride (CCl4) induced liver damage in albino...
Phytochemical Screening Antioxidant and Alpha-glucosidase Inhibitory Activities of Fagopyrum tataricum L. Extract
Objective: The objective of this work was the screening of different phytoconstituents and invitro antioxidant potential and α-glucosidase inhibitory activity of aerial parts of Fagopyrum tataricum. Methods: Preliminary...