Kigelia africana Stem Bark, Fruit and Leaf Extracts Alleviate Benzene-induced Leukaemia in Rats
Journal Title: Journal of Pharmaceutical Research International - Year 2017, Vol 18, Issue 2
Abstract
Aims: This study was aimed at evaluating the potential leukaemia chemotherapeutic activities of various extracts of Kigelia africana stem bark; fruit and leaf by using a benzene-induced model of leukaemia to validate its folkloric use. Evidences from African herbal medicine and traditional applications have shown that Kigelia africana plant has several beneficial therapeutic properties against microbial infections and cancer cell lines. Study Design: Experimental study. Place and Duration of Study: Department of Biomedical Science, College of Health Sciences, Ladoke Akintola University of Technology, Osogbo, Nigeria and study was conducted between August, 2016 and November, 2016. Methodology: Rats were administered 0.2 mL of benzene solution intravenously through the tail 48-hourly for 4 weeks, tested periodically and observed till leukaemia developed prior to treatment with respective extract of the Kigelia africana stem bark, fruit and leaf in appropriate rat groups after leukaemia was confirmed with haematological protocols. Leukaemic rats were administered with 100 mg/mL contained in 0.5 mL stem bark, 0.5 mL fruit and 0.2 mL of the leaf extract orally by gavage using oral cannula once daily post leukemia induction for four weeks. Haematological parameters and white blood cells differential counts (lymphocytes) were assessed in both control and treatment groups to determine the leukaemia burden. Results: Kigelia africana treatment using the stem bark, fruit and leaf significantly (P < 0.05) alleviated the anaemia indices and reduced the marked leucocytosis usually associated with leukaemia toward the negative control level when compared with the leukaemia control group. Antileukaemic activity however appears to be highest in stem bark, and least in the leaf. Conclusion: This study revealed the potential of ethanol extracts of Kigelia africana stem bark, fruit and leaf to reverse leukaemic effects in benzene-induced leukaemia bearing wistar rats and this suggest that the extracts might be promising natural, non-toxic and anticancer agents.
Authors and Affiliations
Akanni E. Olufemi, Olaniran I. Omotayo, Akinbo B. David, Iyiola Monjeed, Ogunlade Adebola, Sanni Bilikis, Adejumo Temitope
Keywords
Related Articles
- EP ID EP312906
- DOI 10.9734/JPRI/2017/34625
- Views 144
- Downloads 0
Effect of Formulation Variables on the Release of Letrozole from Natural Biodegradable Polymeric Implants
Aim: Letrozole, a non-steroidal aromatase inhibitor, prevents the body from producing its own estrogen. The objective of the present study was to explore the fabrication and evaluation of natural biodegradable polymeric...
In vitro Efficacies of Some Nigerian Medicinal Plant Extracts against Toxigenic Aspergillus flavus, A. parasiticus and A. ochraceus
The aim of this work was to find an alternative to chemical fungicides currently used in the control and prevention of activities of toxigenic Aspergillus flavus, A. parasiticus and A. ochraceus in food and feed. The anti...
Natural Sources of Taxol
Taxol® is the most successful anticancer agent developed in the last 50 years. The alkaloid taxol and other taxoids were at first isolated from T. brevifolia. Because of the small yield that threatened existence of the n...
Antihyperglycemic and Antihyperlipidemic Activity of Sida spinosa linn. Root in Streptozotocin- Induced Diabetic Rats
Based on ethnobotonical approaches the ethanolic extract of the plant Sida spinosa Linn. has been traditionally claimed to have hypoglycemic properties. Aim: Evaluation of Antihyperglycemic and antihyperlipidemic activit...
Gene Expression Profiling of Triple Negative Breast Cancer Cells Treated with Afatinib
Purpose: To investigate gene expression profile changes in triple negative breast cancer cells (MDA-MB-231) treated with afatinib. Methods: Differential expression of 84 genes commonly involved in breast cancer carcinog...