Lactate Dehydrogenase as a Biochemical Marker of Adverse Pregnancy and Fetal Outcome in Preeclampsia: A Comparative Study
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2018, Vol 17, Issue 8
Abstract
Aims: Current study has been done to analyse the serum levels of lactate dehydrogenase (LDH) as a prognostic marker for pre-eclampsia and to substantiate the severity of preeclampsia and adverse pregnancy outcome. In this study serum maternal LDH levels was done after 32 weeks of gestation to evaluate the serum LDH as a predictive biochemical marker for feto-maternal outcome in pre-eclampsia. Method: In this study total 80 patients were selected as per the inclusion and exclusion criteria. Out of 80 patients, 40 normotensive patients included in Group 1 which served as control group and other 40 patients with preeclampsia were selected as per aforementioned criteria and categorised as Group 2. In Group 2, 29 patients had mild preeclampsia, 6 developed severe preeclampsia and 5 developed eclampsia. Results and Discussion: The number of babies with Apgar score (at 1 & 5 minutes) < 7 was significantly more in patients of group 2. There was significant higher rate of neonatal complications like RDS, sepsis, IVH, early neonatal death and stillbirth among the babies of group 2. Maternal complications like eclampsia, placental abruption, DIC, HELLP syndrome, ARF and maternal morbidities were significantly more in patients of group 2. The number of babies with low Apgar score at 5 minutes was significantly more in cases of higher LDH levels. Neonatal complications were significantly higher in cases with higher LDH values, Maternal complications were higher in group 2 but when comparison was done in subgroups according to LDH levels there was no significant difference. Conclusion: Serum levels of lactate dehydrogenase can be used to predict the feto-maternal outcome in preeclampsia. It can be used as a biochemical marker of adverse pregnancy and fetal outcome in preeclampsia.
Authors and Affiliations
Dr. Namrata Parida, Dr. Kumari Anamika, DR. NANDINI GOSWAMI, DR. DEBARSHI JANA
Keywords
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- EP ID EP381118
- DOI 10.9790/0853-1708068490.
- Views 91
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