Lactogenic studies of Stachytarphetajamaicensis Linn. (Vahl) family (Verbenaceae)leaves on serum prolactin level of lactatingalbino rats.
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2016, Vol 11, Issue 4
Abstract
Theeffect of crude methanol extract (CME) and fractions (n-hexane, ethyl acetate, n-butanol and water) of Stachytarphetajamaicensis (SJ) leaves were evaluated on serum prolactin (PRL) secretionin albino rats. Female rats that received oral doses (200, 400 or 800 mg/kg) of CME during their first lactation showed a dose-dependent significant increase (P<0.05) in the serum prolactin level when compared to control group. However, the ethyl acetate fraction in the fraction-treated rats during their first lactation exhibited the highest activity when compared to the control with potency greatly higher than the standard drug metoclopramide. The order of activity of the fractions is: EF > BF > HF > WF (800 mg/kg) respectively. The estrogen-primed treated rats produced a high serum PRL concentration compared to the non-primed rats.In addition, mammary gland of estrogen-primed rats treated with the CME and fractions showedclear lobulo-alveolar development with milk secretion. The acute toxicity test of CME and fractions of SJ indicated that the plant is safe as the LD50 was found to be above 5000 mg/kg. This study demonstrates that SJ leaves can stimulate PRL secretion in the female rats which supports its traditional usage in lactating women.
Authors and Affiliations
Odoh, U. E, Udodeme, H. O, Ugwu, N. P, , Diovu, E. O, Ezugwu C. O.
Keywords
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- EP ID EP385629
- DOI 10.9790/3008-1104037989
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