Langerhans Cell Histiocytosis and Intracranial Germinoma: Are Immunohistology Techniques Helpful in Distinguishing Two Entities?
Journal Title: Journal of Neurological Sciences-Turkish - Year 2006, Vol 23, Issue 3
Abstract
Langerhans cell histiocytosis (LCH) is a clonal proliferative disease of the Langerhans cell. Langerhans cell bears abundant eosinophilic cytoplasm mainly associated with a matrix rich in eosinophils, mononuclear and multinucleated giant cells, neutrophils and mature lymphocytes. In the same way intracranial germinoma (ICG) consists of neoplastic germ cells having relatively moderate and/or abundant cytoplasm associated with an inflammatory background rich in lymphocytes. Histopathologic differentiation between ICG and LCH might be troublesome in some case. So far presence of eosinophils is accepted to be a crucial clue in differential diagnosis. In contrary, our experience emphasized eosinophils are present in both pathologic entities, i.e. LCH and ICG. We aim to document similarities and dissimilarities LCH and ICG, and frequency of eosinophils in ICG. Cases were obtained from the archives of pathology laboratory, Marmara University Hospital, Institute of Neurological Science. A series consisted of 10 ICG and 11 LCH specimens were obtained within a time period of 8 years, 1995 to 2003. We performed specific monoclonal antibodies against S-100, CD68, CD1a, PLAP, vimentin and Ki-67. Six cases were female and five cases were male of the LCH cases. If ICG nine cases were male and one case were female. S100, CD1a, CD68, vimentin were stained positively in the LCH. PLAP was stained positively in the ICG. MIB-1 index (detection anti-Ki-67 positive cells / overall population under investigation) value was remarkably higher in ICG. Although eosinophils were found to be almost in all LCH cases, in contrary in some of ICG’s. By conclusion, it clearly indicates that presence of the eosinophils should not be accepted as a specific criterion to be used distinguishing ICG from LCH.
Authors and Affiliations
Ahmet MİDİ, Süheyla BOZKURT, Özlem YAPICIER, Aydın SAV
Keywords
Related Articles
- EP ID EP82422
- DOI -
- Views 140
- Downloads 0
Vestibular Evoked Myogenic Potentials in Subject With Superior Canal Dehiscence Syndrome
Superior canal dehiscence syndrome (SCDS) is characterized by absence of the roof of the superior semicircular canal. Sound stimuli of higher decibels can cause vertigo and oscillopsia in these patients. A 38-year-old la...
Medial Prefrontal Cortex in Modifying Intermale Aggression Via Oxytocin Released in Bed Nucleus Stria Terminalis
The prefrontal cortex (PFC) plays an important role in the integration of cognitive and affective behaviour and regulating autonomic and neuroendocrine functions. We want to investigate the relationship between destroyed...
The Impressive Factors On Functional Recovery Of The Upper Extremity In Hemiplegic Patients
The purpose of this study was to describe the association between motor and sensorial impairment, to establish the relation to age, hemiplegic side, gender and emotion in ischemic stroke and to determine the factors, inf...
Akromegali ile Oto-immün Tiroid Hastalığının Birlikteliği
Amaç: Yazıda akromegali tanısı alan ve aynı zamanda oto-immün tiroid hastalığı eşlik eden iki vaka sunulmuş olup, akromegali ile oto-immün tiroid hastalığı birlikteliği tartışılmıştır. Yöntem: Vaka sunumu Sonuç: Ak...
Meningiomalarda Proliferatif MIB-1 İndeksi:Histolojik Alt Tipler ve Dereceleri ile İlişkisi
87 hastada meningiomaların proliferasyon potansiyelerini Ki-67 antijenine karşı MIB-1 antikoru kullanarak inceledik ve bu değerleri, meningiomaların histopatolojik alt tipleri ve dereceleri ile karşılaştırdık. MIB-1 bağl...