Levels of Circulating Reticulocytes-C4d: Is There Link to Disease Activity in Patients with SLE?
Journal Title: International Journal of Health Sciences and Research - Year 2017, Vol 7, Issue 1
Abstract
Objective: The determination of cell-bound complement activation products (CB-CAPs), such as C4d linked to reticulocyte (R-C4d), are potential biomarkers of disease activation state. Within this context, this cross-sectional study aimed to assess whether, in SLE, R-C4d levels can be predictors of the disease activity in a set of patients selected from Brazilian population. Method: Forty patients with SLE confirmed by the American College of Rheumatology (ACR) classification criteria who were assessed at the time of the visit to the clinic using the SLEDAI-2K index (Systemic Lupus Erythematosus Disease Activity Index 2000) were recruited, besides to 20 adult healthy subjects (controls). Patients with SLEDAI≤ 4 were classified as having low disease activity (SLE-I, n = 20) and those with SLEDAI > 4 as carriers of active disease (SLE-A, n = 20). Peripheral blood samples were collected in EDTA with subsequent separation of reticulocytes population and analyze by flow cytometry to determine the levels of R-C4d. Results: A positive correlation between R-C4d levels and SLEDAI 2K was observed. Significant differences between controls and LES-A (p <0.0001), and between LES-I and LES-A (p <0.0001) were observed. Conclusion: Since reticulocytes are present in the peripheral blood for a period of only 24-48 hours and then turning into mature erythrocytes, higher levels of R-C4d may reflect early active disease. Thus, increased R-C4d expression may be a useful tool for screening disease severity at initial diagnosis and for monitoring disease status of patients.
Authors and Affiliations
Karine Silvestre Ferreira
Keywords
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