Levels of Oxidized Low-Density Lipoprotein and High Sensitive C-Reactive Protein in Retinal Vascular Occlusions: A Pilot Study
Journal Title: Journal of Advances in Medical and Pharmaceutical Sciences - Year 2014, Vol 1, Issue 1
Abstract
Background: Oxidized low-density lipoprotein (OX-LDL) is believed to be a key trigger factor in the genesis of atherosclerosis. It has been postulated that it can activate inflammatory mediators such as high sensitive C-reactive protein (hs-CRP), interleukin 6 (IL6), and tumour necrosis factor (TNF). These mediators have been demonstrated to have an atherogenic effect. Aims: This pilot study examined levels of OX-LDL and hs-CRP in patients with retinal vascular occlusive disorders. Methods: We enroled 7 patients with retinal vascular occlusions during a two-month period. A high sensitive CRP of greater than 3mg/l was considered significantly elevated and a median oxidised LDL value greater than 59 U/L was considered significantly elevated. Results: There were 4 cases of retinal vein occlusion, 1 case of amaurosis fugax, 1 case of cilioretinal artery occlusion and a case of cholesterol embolus in the retinal vasculature. Mean OX-LDL (55.6±21.1 U/L) was borderline, but within the normal range (<59 U/L) but hs-CRP (3.9±3.1 mg/l) were elevated compared to the normal range (0 -3 mg/l). Oxidized LDL was elevated in three patients (43%), and bordeline (between 55 and 59 U/L) in two patients (28%). No significant correlation was found between hs-CRP and OX-LDL values (Pearson’s correlation: r = 0.256; p = 0.456). Conclusion: This study is the first to suggest that OX-LDL and hs-CRP may be elevated in retinal vascular disease. Further investigations are required to determine the significance of these findings.
Authors and Affiliations
Zubair Idrees, Ian Dooley, Brian Power, Aaron Yeung, Marie Hickey Dwyer
Keywords
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- EP ID EP342664
- DOI 10.9734/JAMPS/2014/11341
- Views 103
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