Ligand Binding Assays in the 21st Century Laboratory: Platforms
Journal Title: The AAPS Journal - Year 2012, Vol 14, Issue 1
Abstract
A high level of precision is required to generate reproducible bioanalytical results for the measurement of drug, biomarker concentrations, and detection of immunogenic responses. Precision for LBAs analytical assays used in support regulated studies should be less than 20% coefficient of variation (12,20). A platform with high level of precision could reduce the random error of the analytical method, thus facilitating better analytical precision and more accurate monitoring of therapeutic and biomarker concentrations, immune responses, and potency measurements.
Authors and Affiliations
Franklin P. Spriggs, Zhandong Don Zhong, Afshin Safavi, Darshana Jani, Narasaiah Dontha, Anita Kant, Jenny Ly, Lia Brilando, Karolina Österlund, Nathalie Rouleau, Saloumeh Kadkhodayan Fischer, Martin Boissonneault, Chad Ray
Keywords
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- DOI 10.1208/s12248-012-9321-1
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