Lipid Profile in Normotensive and Hypertensive Pregnant Women-A Randomized prospective study
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2018, Vol 17, Issue 8
Abstract
Hypertension (HTN) during pregnancy is one of the leading causes of maternal and perinatal morbidity and mortality. The aim of our study was to evaluate the alteration of serum lipid profile during normotensive and hypertensive pregnancy. A cross-sectional comparative study was performed at tertiary care teaching hospital. Blood samples were collected from normal pregnant women(Group 1, n=50) & women with already diagnosed preeclampsia(Group 2, n=50) in third trimesters of pregnancy& concentration of serum triglyceride, VLDL, LDL, totalcholesterol & HDL was compared. Results: Group2 was associated with a significant rise in triglyceride (208.80±7.30 mg%vs. 109.20±1.29 mg %) compared to group1. There wasfall in mean HDL cholesterolconcentration in group2 (37.52 ± 0.74 mg % as against 38.9 mg ± 0.37mg % in group1) (P<0.05). The mean values of total cholesterol in normotensives was 169.74 ± 3.98 mg/dl and in hypertensive 235.40±6.02 mg %) (P<0.0001). Also LDL-cholesterol was significantly increased in group2 (mean 153.88±6.21mg %) and 129.94 ± 3.73 mg % in group1 (P < 0.0001). Very LDL-C was significantly increased in hypertensive pregnancies with mean 45.36 ± 1.99) mg% while in normotensives it was 22.24± 0.71 mg%. We conclude that human gestation is associated with an ‘atherogenic’ lipid profile that is further enhanced in preeclampsia and this profile may be a potential contributor to endothelial cell dysfunction. We recommend that pregnant female with serum lipid concentrations higher than normal pregnancy should be suspected to development of preeclampsia.
Authors and Affiliations
Khadke Chaitali Venkatesh, DrSiddique Abdul Mubashir
Keywords
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- EP ID EP381274
- DOI 10.9790/0853-1708092428.
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