Lipoprotein Lipase Expression, Serum Triacylglycerol and Tissue Lipid Deposition in Rats Fed on Switching Type of Diet and Treated with Glycyrrhizic Acid
Journal Title: European Journal of Medicinal Plants - Year 2014, Vol 4, Issue 2
Abstract
Aims: To determine the anti-hyperglycaemic and anti-hyperlipidaemic effects of glycyrrhizic acid (GA), the root extract of Glycyrrhiza glabra in rats with switching type of diet i.e. between normal diet (ND) and high-fat diet (HFD). Study Design: In vivo study. Place and Duration of Study: School of Science, Monash University Sunway Campus between January 2010 and October 2010. Methodology: Sixteen Sparague-Dawley rats were divided into two groups having eight animals each i.e. group A- ND+GA→ HFD+GA; group B- ND+GA→HFD+no GA. Rats were fed with the corresponding diet and GA (100 mg/kg) for 28 days. The blood glucose, insulin and triacylglycerol levels, lipoprotein lipase expression in the liver, kidney, heart, abdominal muscle (AM), quadriceps femoris (QF), subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT) and tissue lipid deposition were measured. Results: No significant difference in blood glucose levels between groups. GA significantly lowered (P=.05) triacylglycerol in rats fed on a ND with GA and later switched to a HFD without GA (group B) compared to rats fed on a ND with GA and later switched to a HFD with continuous GA supplementation (group A). For LPL expression, group B had significant lower (P=.05) LPL expression in the liver, AM, kidney and heart than group A. Group A had significantly smaller (P=.05) size of VAT than group B. Conclusion: These findings may indicate the role of GA in lowering blood glucose and triacylglycerol in subjects who had a switch from a ND with GA to a HFD without GA but not in those who had a switch from a ND with GA to a HFD with continuous GA supplementation.
Authors and Affiliations
Hui Ping Yaw, So Ha Ton, Shing Wei Ng, Khalid Abdul Kadir
Keywords
Related Articles
- EP ID EP350018
- DOI 10.9734/EJMP/2014/6700
- Views 136
- Downloads 0
In-vitro Anti-bacterial Effects of Jatropha curcas on Salmonella Typhi and Salmonella Typhimurium Isolated from Presumptive Typhoid Fever Patients in Akure Metropolis, Nigeria
Aim: The present study determined the in-vitro anti-bacterial effects of Jatropha curcas on Salmonella Typhi and Salmonella Typhimurium isolated from presumptive typhoid fever patients in Akure metropolis, Nigeria. Stud...
In Silico MicroRNA Identification from Stevia rebaudiana Transcriptome Assembly
MicroRNAs are a class of endogenous, approximately 22 nucleotides in length noncoding RNA, which is evolutionary conserved and mediates post-transcriptional gene regulation. MicroRNA play a crucial role in development of...
The Antimicrobial and Phytochemical Analysis of the Leaves of Aspilia africana on Clinical Isolates
The uses of medicinal plants for treatment of various infections in traditional communities have been an age-long practice. This provides the rationale to study medicinal plant extracts as a possible source of alternativ...
Adventitious Bud Formation and Plantlet Regeneration of Achyrocline satureoides-A Multipurpose Medicinal Plant
Adventitious bud regeneration was achieved from hypocotyls, cotyledons and leaf explants of Achyrocline satureioides. Organogenesis was induced from every explant cultured on Murashige and Skoog semisolid medium (plus su...
Pharmacological Potential of Tricosanthes tricuspidata and Clematis montana for Hypoglycemic and Antioxidant Activity
The aim of present study was to evaluate the antidiabetic and antioxidant potential of Tricosanthes tricuspidata and Clematis montana leaf and root extracts. On the basis of toxicity studies a dose of 200 mg/kg body weig...