Liposomes as carriers for the delivery of active substances to the skin
Journal Title: Engineering of Biomaterials / Inżynieria Biomateriałów - Year 2015, Vol 18, Issue 130
Abstract
Since ancient times cosmetics and dermatological medicines have been applied to the skin. Presently growing interest in topical administration in order to achieve therapeutic or good cosmetic effects can be noticed. Effectiveness of medicines topically applied is not limited only to the skin, but due to the absorption of medical substances, the drug can reach subdermal tissues or circulatory system. Similarly, active substances in cosmetic can act both within epidermis and dermis layers, and can enter the bloodstream. Liposomes are vesicles which are surrounded by a lipid bilayer. They are created spontaneously from phospholipids in aqueous environment and they are filled with a small amount of aqueous solution of hydrophilic active substances. Incorporation of micro and macro molecules in liposomes provides stabilization, constant release during the time unit and targeted drug delivery in hostile environment. Biodegradable drugs protected from oxidation improve protein stabilization and can be administered through various routes. Liposomes are used in numerous applications, including cosmetics and biotechnology, microbiology, and also pharmaceutical and food industry. Moreover, nanomedicine developments are crucial for carrying drugs, and liposomes versatility leads to increase in their application in medical fields, like diagnosis and therapy.
Authors and Affiliations
U. Goik, I. Załębska-Żyłka, A. Pietrzycka
Keywords
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Liposomes as carriers for the delivery of active substances to the skin
Since ancient times cosmetics and dermatological medicines have been applied to the skin. Presently growing interest in topical administration in order to achieve therapeutic or good cosmetic effects can be noticed. Effe...