Liver functions in patients with obstructive sleep apnea syndrome
Journal Title: The European Research Journal - Year 2018, Vol 4, Issue 4
Abstract
Objective: Previous studies showed that obstructive sleep apnea syndrome (OSAS) was associated with liver diseases such as elevated liver enzyme levels and hepatic steatosis. The aim of this study was to assess the relationship between serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels and OSAS and its severity. Methods: A total of 617 patients who underwent PSG (polysomnography) between January 2016 and May 2017 were evaluated in this study. AST, ALT, total cholesterol, triglyceride levels and body mass index were analyzed. The data were analyzed using the Student t-test, ANOVA, Chi-square test, and Pearson's correlation coefficient. Results: Five hundreds and thirty patients with OSAS and 60 healthy controls were included in the study. Of the patients in the OSAS group, 17.7% had an elevated ALT level and 7.9% had an elevated AST level. There was a statistically significant difference in ALT and AST levels between the OSAS and control groups (p < 0.001 and p < 0.001, respectively). In the OSAS group, there was a statistically significant positive relationship between serum ALT and AST levels and apnea-hypopnea index (AHI), apnea index, oxygen desaturation index. Both AST and ALT levels were statistically significantly higher in obese patients than in non-obese patients (p < 0.001 and p < 0.001, respectively). ALT level was statistically significantly higher in patients without hypertension than in patients with hypertension (p < 0.001). In OSAS patients without hypertension, there was a statistically significant relationship between serum ALT and AST levels and AHI (r = 0.223, p < 0.001 and r = 0.142, p = 0.007; respectively). Conclusion: OSAS is a risk factor for elevated liver enzyme levels. Hypoxia plays an important role on liver enzymes in OSAS patients.
Authors and Affiliations
Seda Beyhan Sağmen, Elif Torun Parmaksız, Sevda Şener Cömert, Ali Fidan, Banu Salepçi
Keywords
Related Articles
- EP ID EP409218
- DOI 10.18621/eurj.381906
- Views 111
- Downloads 0
Investigation of effects of neurotrophic factors on painful diabetic neuropathy: an experimental study
Objective: We have studied the effects of neurotrophin-4 (NT-4) different doses on the pain levels of streptozocin-induced diabetic rats. Methods: Thirty-five 3-week-old male rats were used. After induction of diabetes...
Evaluation of dry eye-associated symptoms and signs after microincision cataract surgery
Objectives. To evaluate the effects of microincision cataract surgery on dry eye-associated symptoms and signs. Methods. This prospective study included 40 eyes of 32 patients. Microincision cataract surgery was performe...
Wrongs known as right in thyroid scintigraphy and uptake study
Objectives: Thyroid scintigraphy using 99mTc-pertechnetate is commonly used to study function and structure of thyroid gland. Pin-hole collimator is generally preferred in thyroid scintigraphy and uptake studies. The pur...
Neovascular age-related macular degeneration: 18-month outcomes of aflibercept treatment in patients resistant to ranibizumab
Objectives: Aim of this study is to investigate the effect of intravitreal aflibercept therapy in an 18-month period in patients with recurrent neovascular age-related macular degeneration resistant to intravitreal ranib...
Cardioprotective effect of vitamin D and melatonin on doxorubicin-induced cardiotoxicity in rat model: an electrocardiographic, scintigraphic and biochemical study
Objectives: Doxorubicin (DOX) is an antineoplastic drug that is widely used in chemotherapy but its cardiotoxicity is the most important side effect that limits the clinical use of this drug. We investigated DOX treatmen...