Liver transplantation followed by autologous stem cell transplantation for acute liver failure caused by AL amyloidosis. Case report and review of the literature

Journal Title: Annals of Hepatology - Year 2016, Vol 15, Issue 4

Abstract

Hepatic involvement in AL amyloidosis may present as acute liver failure. Historically, liver transplantation in these cases has achieved poor outcomes due to progress of amyloidosis and non-hepatic organ damage. In the era of bortezomib treatment, the prognosis of AL amyloidosis has been markedly improved and may also result in better post-transplant outcomes. We present a case of isolated acute liver failure caused by AL amyloidosis, bridged to transplantation with bortezomib and treated with sequential orthotopic liver transplantation (OLT) and autologous stem cell transplantation. The patient is in stable remission 3 years after OLT.

Authors and Affiliations

Mayada Elnegouly, Katja Specht, Heinz Zoller, Edouard Matevossian, Florian Bassermann, Andreas Umgelter

Keywords

Related Articles

Addition of pentoxifylline to pegylated interferon-alpha-2a and ribavirin improves sustained virological response to chronic hepatitis C virus: a randomized clinical trial

[b]Background and aim.[/b] The commonly accepted treatment for hepatitis C virus (HCV) infection, pegylated interferon alpha (PEG INF-alpha) and ribavirin, leads to 50-60% of sustained virological response (SVR). On the...

Cultural Validation of the Transplanted Organ Questionnaire (TOQ) for the Brazilian Population

Background and rationale. The Transplanted Organ Questionnaire (TOQ), developed in France, is a disease-targeted instrument designed to evaluate what the transplanted organ represents to the recipient in patients who hav...

Treatment of HCV infection in patients with cirrhosis

The treatment of patients with cirrhosis has the following purposes: to prevent the complications of the disease; to allow for the regression of cirrhosis; and to prevent reinfection in the graft in patients undergoing l...

Two Cases of Primary Hepatic Neuroendocrine Tumors and a Review of the Current Literature

Neuroendocrine tumors comprise approximately 1-2% of all gastrointestinal tumors, and while the liver is the most common site for metastasis of these tumors, primary hepatic neuroendocrine tumors are very rare entities....

Download PDF file
  • EP ID EP78606
  • DOI 10.5604/16652681.1203163
  • Views 136
  • Downloads 0

How To Cite

Mayada Elnegouly, Katja Specht, Heinz Zoller, Edouard Matevossian, Florian Bassermann, Andreas Umgelter (2016). Liver transplantation followed by autologous stem cell transplantation for acute liver failure caused by AL amyloidosis. Case report and review of the literature. Annals of Hepatology, 15(4), 592-597. https://www.europub.co.uk/articles/-A-78606