Local Effects of Papaverine on Normal, Atherosclerotic, and Vasospastic Carotid Arteries of Rabbits: An Experimental Study
Journal Title: Bagcilar Medical Bulletin - Year 2017, Vol 2, Issue 2
Abstract
Objective: Papaverine is a direct-acting vasodilating agent that is frequently used in the treatment of vasospasm after subarachnoid hemorrhage. However, not much knowledge is available about the effect of papaverine on atherosclerotic vessels. Material and Methods: Twenty-four New Zealand-type male rabbits were divided into 4 groups: normal, atherosclerotic, normal vasospastic, and atherosclerotic vasospastic vessels. The atherosclerotic groups (2 and 4) were fed with high cholesterol diet and the other groups with a normal diet for 4 weeks. Cholesterol levels were measured before and after exposure to these diets. In groups 3 and 4, a vasospasm model for common carotid arteries was established. In all subjects, papaverine was applied topically on the left common carotid artery (study subgroups a) and serum physiologic on the right (control subgroups b). Before and 10, 20, 30, 40, 50, and 60 minutes after topical application, vessel diameter was measured and compared between the groups. Histological evaluation of the artery was also performed in all subjects. Results: In the atherosclerosis groups (Groups 2 and 4), blood cholesterol levels were significantly higher after 4 weeks of high cholesterol diet. Atherosclerosis and vasospasm development were confirmed with histological examination in the respective groups. Papaverine application lead to significant dilation in all groups according to the SF application. Its most prominent vasodilating effect was seen in normal vessels, while its effect gradually decreased from groups 2 to 4. Conclusions: The vasodilating effect of papaverine decreased in the presence of atherosclerosis. New experimental and clinical studies are required to determine the effective local papaverine doses in atherosclerotic cases.
Authors and Affiliations
Azmi Tufan, A. Celal Iplikcioglu, Murat Cakabay, Mustafa Aziz Hatiboglu, Deniz Ozcan
Keywords
Related Articles
- EP ID EP50375
- DOI 10.5350/BMB20170522075513
- Views 228
- Downloads 0
Propofol and Seizure-Like Activity
Objective: In this study, seizure-like activity, injection pain, and the presence of dreams after propofol injection were assessed. Material and Method: One hundred women scheduled for obstetric and gynecologic procedur...
The Correlation of Pain Catastrophizing Scale and Sedation in Patients Undergoing Gastroscopy
Objective: Catastrafization is defined as considering the worst possible consequence of events and danger and increasing the likelihood of this. In this study, the Catastropization scale applied to patients to compare pa...
Local Effects of Papaverine on Normal, Atherosclerotic, and Vasospastic Carotid Arteries of Rabbits: An Experimental Study
Objective: Papaverine is a direct-acting vasodilating agent that is frequently used in the treatment of vasospasm after subarachnoid hemorrhage. However, not much knowledge is available about the effect of papaverine on...
Individuals with Eating Disorder Symptoms Have an Increased Risk of Nightmares
Objective: This preliminary study was aimed to examine if individuals with eating disorder symptoms have a higher incidence of nightmares. Additionally, the possible influence of general psychological distress on the rel...
Comparing The Rate of Radiological and Clinical Adjacent Segment Degeneration After Simple Anterior Cervical Discectomy Versus Discectomy Plus Fusion
Objective: To evaluate and compare the radiological changes on adjacent mobile segments and clinical findings in patients having undergone single-segment simple anterior cervical discectomy versus discectomy plus interv...