Low folic acid serum concentration as one of the factors leading to basal cell carcinoma development
Journal Title: Postępy Nauk Medycznych - Year 2012, Vol 25, Issue 10
Abstract
Basal cell carcinoma (BCC) is the most common neoplasm in Caucasian population, it represents over 80% of newly diagnosed tumors. Folic acid insufficiency has been recently considered as a risk factor for several cancers.<br><b>Aim. </b>To assess the contribution of folic acid metabolism in the process of carcinogenesis in patients with BCC by determining the concentration of folic acid in the serum of patients with BCC and in control group.<br><b>Material and methods.</b> Study group included 125 Caucasian subjects, 79 persons (41 women, 38 men, median age – 60.2 years, phototype: I/II – 20, III – 52, IV – 7) with BCC diagnosed on the basis of histopathological examination and 46 healthy volunteers (21 women, 25 men, median age – 58.4 years, phototype: I/II – 10, III – 28, IV – 8). In all patients serum folic acid concentration was measured with the use of Vitamin Folic Acid Test (DRG Vitamin Folic Acid, Mountainside, USA).<br><b>Results. </b>Folic acid concentration was significantly higher in a control group than in BCC patients (median 16.5 μg/l vs. median 9.6 μg/l; respectively; p < 0.001). In most of the subjects both from control group and with BCC folic acid serum concentration was within normal limit.<br><b>Conclusions.</b> Based on the obtained results and literature data we may conclude that the folic acid is involved in BCC development and its insufficiency may be concerned as one of the risk factors leading to skin cancerogenesis.
Authors and Affiliations
Małgorzata Drobnicka-Stępień, Joanna Narbutt, Irmina Olejniczak, Anna Sysa-Jędrzejowska, Aleksandra Lesiak
Keywords
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