Lupus Anticoagulant in PIH and Pregnancy Outcome
Journal Title: International Journal of Medical and Health Sciences - Year 2017, Vol 6, Issue 1
Abstract
Background: Hypertensive disorders continue to occur globally, complicating 5-20% of pregnancies. Antiphospholipid antibodies are one of the risk factors in the development of pregnancy induced hypertension. Aim of this study is to determine prevalence of lupus anticoagulant (LAC) in PIH and its effect on foetal outcome. Materials and Method: This prospective study was conducted at Department of General Medicine and Obstetrics of a tertiary care centre over one year. The study comprised of 100 third trimester pregnant women, aged 18-34 years with blood pressure more than 140/90 mm Hg on two occasions at least 6 hours apart. 50 normal pregnant women in third trimester comprised control group. Results: In the present study, the prevalence of LAC in the hypertensive women in their third trimester was found to be 14%. LAC positivity was found in greater percentage among severe hypertensive patients than in moderate hypertensive group (16.6% Vs 4.8%). Conclusion: In the present study, it was found that LAC is associated with severe PIH, thrombocytopenia, IUGR, increased operative interference and increased neonatal mortality. Thus it is concluded that LAC should be screened in all patient who have PIH and bad obstetric history.
Authors and Affiliations
Abhishek Singhai, Shiv Chadha
Keywords
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