Lutein and Zeaxanthin Isomers effect on Sleep Quality
Journal Title: Biomedical Journal of Scientific & Technical Research (BJSTR) - Year 2018, Vol 5, Issue 5
Abstract
Purpose: Excessive exposure to short-wavelength visible (“blue”) light may damage retinal cells and lead to macular degeneration. This study is to assess the effects of macular carotenoids [L/Zi, lutein, zeaxanthin, and meso-zeaxanthin] on visual performance, function, computer use exposure causing symptoms and sleep quality in healthy subjects. Methods: We carried out a double-blind, placebo-controlled randomized (DBPCR) study in 48 healthy young adults (mean age = 21.2 years, males and females, non- smokers, and Body mass index (BMI) <27 kg/m2). Subjects included in the study was based on minimum at least 4 hours / day (outer side activity & screen time exposure of electronic devices). Subjects were randomly assigned to ingest daily either a placebo (PLA, Safflower oil capsule/day, n = 13), or 20 mg L/Zi (20 mg L/4 mg Zi/day, n = 35). Macular pigment optical density (MPOD), contrast sensitivity (CS), critical flicker fusion (CFF), serum lutein (L) and zeaxanthin (Z) were assessed. Sleep quality assessed and a questionnaire was used to assess the daily use (in hours) of computers/tablet/laptops/smart phones (CDU) and physical symptoms. Statistical significance set at p<0.05. Results and Conclusion: L/Zi supplementation significantly improved MPOD, CFF and CS [p < 0.05], serum L, Z and ratio of L/Z (p<0.0001) increased over placebo. Sleep quality improved (p<0.05), reduced eye fatigue, eyestrain and headache episodes were observed. Eye fatigue was significantly correlated with CFF and CS at baseline. No adverse events were observed among participants. Visual performance, function, sleep quality and symptoms associated with CDU improved with L/Zi supplementation in healthy subjects. Millions of children and adults use computers at school, work, and home. Extensive viewing of computer screens and an increasing preference for smaller-screen devices that necessitate nearfield viewing (e.g., computers, laptops, tablets and smartphones) can cause eye discomfort, fatigue, blurred vision, and headaches and lead to photo-oxidative damage [1,2]. Based on recent Pew Re search Center surveys, 45% of U.S. adults own a tablet and 73% of U.S. adults own a desktop or laptop computer [3]. Computer use is universal and may lead to significant impact not only on visual comfort and strain but also on occupational productivity [2]. In [3] reported significant differences in median symptom scores with regard to blurred vision during a task (p = 0.03) and the mean symptom score (p = 0.04) was higher for computer use in young, visually-normal subjects [4]. Symptoms such as eyestrain, dry eyes, blurry vision, and eye fatigue are very common from extended computer monitor use [5]. Visible light, such as sunlight, contains all color wavelengths - red, orange, yellow, green and blue – and is colored depending on the energy and wavelength of the spectral bands. According to a study by The Schepens Eye Institute, low macular pigment density may represent a risk factor for Age-related macular degeneration (AMD). Low amounts of macular pigment can result in Inc reased photochemical damage to the photoreceptors and the retinal pigment epithelium (RPE) [6]. In vitro and in vivo studies have shown that too much exposure to blue light damages retinal cells and increases oxidative stress thereby demonstrating that blue light penetrates to the retina [7,8]. Macular carotenoids can be considered for preventing photoreceptor cell degeneration and neutralizing free radicals produced by oxidative stress [7-9]. reported that the retina was most sensitive to short-wavelength light and result to photoxidative damage in the retinal pigment epithelium [10-12]. Computer use and associated symptoms may vary significantly with gender, and a positive correlation was observed between computer-related visual symptoms and the Ocular Surface Disease Index (OSDI), a measure of dry eye [13].
Authors and Affiliations
Melinda Fernyhough Culve, James Bowman, Vijaya Juturu
Keywords
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- EP ID EP591800
- DOI 10.26717/BJSTR.2018.05.001250
- Views 195
- Downloads 0
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