LYSOZYME HYDROCHLORIDE INHIBITS CYTOKINES IN EPITHELIAL CELLS WITH RESPIRATORY SYNCYTIAL VIRUS INFECTION: A BRIEF REPORT
Journal Title: International Journal of Pharmaceutical Sciences and Drug Research - Year 2015, Vol 7, Issue 1
Abstract
Lysozyme hydrochloride, derived from Hen Egg Lysozyme, is one of classical anti-airway inflammatory drugs. It has been widely administered in Japan, but its molecular potential is unknown. To confirm this classical drug as anti-inflammatory agent, pro-inflammatory cytokines in Epithelial Cells infected by RSV with lysozyme hydrochloride were measured. Lysozyme hydrochloride suppressed the production of IL-6, IL-1β, G-CSF although IL-8 and IFN-γ was not changed. Lysozyme hydrochloride inhibits pro-inflammatory cytokines in Epithelial cells infected with Respiratory Syncytial Virus, and may affect to airway inflammation.
Authors and Affiliations
Takayuki Sakurai, Ken Iesato, Seiichiro Sakao, Kengo Saito, Koichiro Tatsumi, Hiroshi Shirasawa
Keywords
Related Articles
- EP ID EP625055
- DOI -
- Views 80
- Downloads 0
DIETARY POLYPHENOLICS SUPPLEMENTATION WITH DRINKING BLACK TEA AMELIORATES GENTAMICIN-INDUCED NEPHROTOXICITY IN MICE
Black tea (Camellia sinensis) supplement on renal disorders has poorly been explored. The present study was aimed to identified essential polyphenols present in black tea and it’s the role in gentamicin (GEN) induced nep...
EFFECT OF LEUKOTRIENE RECEPTOR ANTAGONIST MONTELUKAST ALONG WITH CURCUMIN AGAINST GASTRIC ULCERATION
Curcumin, a yellow pigment in the spice turmeric, has been used for centuries as a treatment for inflammatory diseases. This yellow pigment has anti-secretary property in different experimental ulcer models. Montelukast,...
EVALUATION OF EXTRACTS OF QUALEA PARAENSIS DUCKE FOR THEIR ANTIMICROBIAL, TOXIC AND ANTICHOLINESTERASE ACTIVITIES
Popularly known as red mandioqueira, ‘mandioqueira vermelha’, Qualea paraensis Ducke is a plant species belonging to the family Vochysiaceae, with a natural distribution in the Amazon region. It is used in traditional me...
BIOLOGICALLY ACTIVE TRITERPENES FROM EUGENIA PISIFORMIS CAMBESS. (MYRTACEAE)
In Brazil, Eugenia pisiformis, which belongs to botanical family Myrtaceae occurs in the states of Rio de Janeiro, Espírito Santo, Maranhão and Bahia. A specimen of E. pisiformis collected in Itatiaia National Park, Stat...
FORMULATION AND IN-VITRO EVALUATION OF GASTRO-RETENTIVE FLOATING TABLETS CONTAINING QUETIAPINE FUMARATE
The present study was focused on Gastro-retentive tablets of Quetiapine fumarate using hydrophilic polymers HPMC K 250 PH PRM, HPMC K 750 PH PRM and HPMC K 1500 pH PRM as release retarding agents. WSR 301 was chosen as r...