Maculopapular Rash in a Case of Sacroiliac Joint Tuberculosis, Induced by Pyrizinamide: A Rare Side Effect and a Concern of Compliance

Journal Title: Journal of Medical Science And clinical Research - Year 2018, Vol 6, Issue 2

Abstract

Pyrazinamide is primarily used in the treatment of active tuberculosis as a first line agent. Gastric adverse effects due to Pyrazinamide have been commonly reported. On the contrary, skin rash and photosensitivity as a side effect are seldom observed. We reported a case of maculopapular rash due to Pyrazinamide in a patient on anti-tuberculosis treatment (ATT) for right sacroiliac joint tuberculosis, using three questionnaire systems. The patient developed maculopapular rash on receiving combination ATT. The rash disappeared after discontinuation of the suspected drug. The patient was rechallenged with pyrazinamide, which led to reappearance of rash. The causality and severity were assessed using the Naranjo algorithm, WHO-UMC causality assessment score and Hartwig scale. In developing countries, musculoskeletal tuberculosis has a high prevalence with pyrazinamide as the first line drug. Since rare adverse effects like skin manifestations may lead to non compliance of the patient to the therapy. Hence, awareness, early detection and timely management may hold prime importance

Authors and Affiliations

Dr Swapnil D Patil

Keywords

Related Articles

Role of Mannheim Peritonitis Index in Perforative Peritonitis in Rural Population

Perforative Peritonitis still remains a disease with higher mortality and morbidity rates in rural population of India. The aim of this study was to evaluate the efficacy of Mannheim Prognostic Index in predicting the cl...

Acute Ischemic Infarct in Patient with Russel Viper Bite

Ischemic stroke is rare in patient with snake bite. We report a case a 45year male with alleged history of snakebite with haematological manifestation developed left hemiplegia on second day. CT Brain taken showed hypera...

Autoantibodies and Wrist Synovitis in Early Rheumatoid Arthritis, UltraSonographic Study

Several autoantibodies has been linked to rheumatoid arthritis, diagnosis but its relation to joint synovitis needs to be evaluated. Aim of the work: To investigate the relation between rheumatoid factor, anti-cyclic cit...

Graves Disease Induced Dilated Cardiomyopathy

Gravis’ thyrotoxicosis is rarely complicated with heart failure. Here in, we present a case of 45 years old female without past medical history of cardiac disease who admitted to our hospital for altered mental status. H...

Raised Red Cell Distribution Width as a Risk Assessment Prognostic Tool For Post Myocardial Infarction Patients

Objectives & Aims: The evaluation and identify new prognostic markers suggested in recent studies for coronary heart disease ,raised red blood cell distribution width (RDW) has been found to be associated with poor progn...

Download PDF file
  • EP ID EP486778
  • DOI -
  • Views 73
  • Downloads 0

How To Cite

Dr Swapnil D Patil (2018). Maculopapular Rash in a Case of Sacroiliac Joint Tuberculosis, Induced by Pyrizinamide: A Rare Side Effect and a Concern of Compliance. Journal of Medical Science And clinical Research, 6(2), 135-139. https://www.europub.co.uk/articles/-A-486778