Malignant Transformation of Oral Leukoplakia: Study of 50 Patients
Journal Title: Journal of Advanced Medical and Dental Sciences Research - Year 2018, Vol 6, Issue 11
Abstract
Background: Oral leukoplakia (OL) is the best-known potentially malignant disorder. The objective of this study is to estimate the rate of malignant transformation in a patients with leukoplakia for more than 5 years and identify significant risk factors of OL malignant transformation. Methods: A total of 50 patients with clinical and histopathological diagnosis of OL were retrospectively reviewed. The mean follow-up period was 5.3 years. Results: Among 50 cases, 10 (20 %) OL patients developed oral cancer, with a mean duration of 5.2 years. Statistical analysis revealed that dysplasia was an independent risk factor for OL malignant transformation, but age, gender, lesion site, diet habit, smoking and ethanol intake were not risk factors. Consistent with this result, high-risk dysplastic OL had significantlyhigher malignant incidence than low-risk dysplasia, particularly during the first 2-3 years. Conclusions The utilization of high-risk dysplasia as a significant indicator for evaluating malignant transformation risk in patients with OL was suggested, which may be helpful to guide treatment selection in clinical practice.
Authors and Affiliations
Rathi Rela
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