Mannitol Vs Hypertonic Saline in the Treatment of Increased Intracranial Pressure in Traumatic Brain Injury Patients
Journal Title: Journal of Medical Science And clinical Research - Year 2016, Vol 4, Issue 8
Abstract
Medical management of increased intracranial pressure should include sedation, drainage of cerebrospinal fluid, and osmotherapy with either mannitol or hypertonic saline. The aim of this study is to compare the effects of equimolar doses of 20% mannitol solution and of 7.45% hypertonic saline solution (HS) in elevated intracranial pressure of traumatic brain injury patients. This study was conducted at Mamatha medical college, it includes 20 patients divided into 2 groups; mannitol group (M), and Hypertonic saline(HS)group. A single equimolar infusion (255 mOsm dose) of either 231 ml of 20% mannitol (M)or 100 ml of 7.45% hypertonic saline (HS) administered for 20min. Intracranial pressure, arterial blood pressure, cerebral perfusion pressure,brain tissue oxygen tension, serum sodium and osmolality, and urine output were measured at T0,30,60,90,120 min. The two drugs were efficient in reducing ICP. At 60 mins after the start of theinfusion, ICP was reduced by 44% ±17% of baseline values (mean ± SD) in the mannitol group vs. 33% ±12% of baseline values in the HS group. The CPP was elevated significantly in mannitol group compared to base line values whereas slight elevation was seen in HS group. Significantly greater increase inurine output notice in mannitol than HS, although there was no difference in the vascular filling requirement between the two treatments. HS caused a significant elevation of serum sodium and chlorideat 120 mins after the start of the infusion. It was concluded that equimolar dose of both drugs were effective in treatment of elevated intracranial pressure
Authors and Affiliations
Jagadeesh Babu. K
Keywords
Related Articles
- EP ID EP214042
- DOI -
- Views 108
- Downloads 0
Impaired Systemic Iron Homeostasis and Parkinson's Disease
Introduction: Parkinson's disease is second most prevalent neurodegenerative old age disorder of basal ganglia characterized by tremor at rest, muscle rigidity, slowness of movement (bradykinesia, akinesia), and changes...
Esthetic Rehabilitation of Crown Fracture Utilizing Orthodontic Extrusion and Restorative Modality
INTRODUCTION: Complicated crown fractures involve enamel, dentine and the pulp, whereby the most commonly affected tooth is the maxillary central incisor. Fractures of anterior teeth cause not only esthetic and functiona...
Possible role of Cold Agglutinins in Pathogenesis of Acquired Autoimmune Hemolytic Anemia
Present study relates to the results of detection of high-titer cold anti I antibodies in sera of 3 patients with anemia. Age of the patients ranged from 15 to 67 (median 30) years. Characterization of immune complexes o...
Surgical Management for Spinal Tuberculosis: A Review
Spinal tuberculosis (TB) incidence in both developing and developed countries has dramatically increased, owing to the increase of HIV infection and drug resistance [1,2]. Antituberculous chemotherapy is proven to be ine...
A comparative study of the effect of suture and suture-less techniques on post-operative complications following lower third molar surgery
Background: Lower third molar surgery remains one of the most common surgical procedure in oral and maxillofacial surgery. It has its own risks, and post-operative complications, that influence the recovery period, and a...