Masitinib and its Role in Inhibiting SARS-CoV-2 Infection
Journal Title: Journal of Regenerative Biology and Medicine - Year 2021, Vol 3, Issue 5
Abstract
A drug used successfully in veterinary medicine to treat mast cell tumors in dogs may be effective against COVID-19 and some other viral diseases in humans, according to laboratory experiments and preclinical studies published in Science 2021 [1]. Coronaviruses also require such enzymes. After entering the cells, their genome is first converted into 2 polyproteins, which must be broken down into smaller units. This task is performed by 2 proteases. This is once the main protease 3CL (also called Mpro or nsp5). The 2nd enzyme is the "papain-like" protease, abbreviated PLpro. Drugs that block one of these enzymes could prevent the viruses from replicating in the cells and thus stop the progression of the infection.
Authors and Affiliations
Bittmann S1*, Luchter E1, Weissenstein A1, Bittmann L1 and Villalon G1
Keywords
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- EP ID EP707388
- DOI https://doi.org/10.37191/Mapsci-2582-385X-3(5)-084
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