Masitinib and its Role in Inhibiting SARS-CoV-2 Infection
Journal Title: Journal of Regenerative Biology and Medicine - Year 2021, Vol 3, Issue 5
Abstract
A drug used successfully in veterinary medicine to treat mast cell tumors in dogs may be effective against COVID-19 and some other viral diseases in humans, according to laboratory experiments and preclinical studies published in Science 2021 [1]. Coronaviruses also require such enzymes. After entering the cells, their genome is first converted into 2 polyproteins, which must be broken down into smaller units. This task is performed by 2 proteases. This is once the main protease 3CL (also called Mpro or nsp5). The 2nd enzyme is the "papain-like" protease, abbreviated PLpro. Drugs that block one of these enzymes could prevent the viruses from replicating in the cells and thus stop the progression of the infection.
Authors and Affiliations
Bittmann S1*, Luchter E1, Weissenstein A1, Bittmann L1 and Villalon G1
Keywords
Related Articles
- EP ID EP707388
- DOI https://doi.org/10.37191/Mapsci-2582-385X-3(5)-084
- Views 95
- Downloads 0
The COVID-19 Pandemic and its Impact on Knowledge, Attitude, and Practices Among Dental Students in Davanagere city, Karnataka: A Cross-Sectional Survey
The spread of viral disease in community and its occurrence among healthcare workers is important evidence of person-to-person transition. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was declared as a pa...
Intra-Articular Injection of an Extracellular Vesicle Isolate Product to Treat Shoulder Osteoarthritis in an Athlete
Cadaver and radiographic studies have demonstrated shoulder osteoarthritis (OA) in up to 33% of patients over the age of 60 [1]. Patients that present with shoulder OA have pain, crepitus and loss of glenohumeral motion....
Topical Beta Blockers in Small Infantile Hemangioma: State of the Art?
Infantile hemangiomas (IH) are benign forms of endothelial proliferation in the first 8 weeks of life [1-11]. Leaute-Labreze et al. published the first spontaneous cases of IH treated with beta blockers in 2008 due to th...
Homologous Use of Umbilical Cord Tissue for Knee Pain
Context: Injection with homologously-used umbilical cord tissue allograft has not been adequately studied in patients suffering from knee pain. Objectives: The goal of this study is to determine if knee pain subjects...
Down Syndrome: Regenerative Medicine Taming the Over-Expressive Trisomy (Chromosome 21) Genes
Trisomy silencing is an important factor in curing Down syndrome. As per a study in various experiments, XIST Transgene transforms chromosome 21 in stem cells. This Transgene normalizes cell function and development upon...