Abstract

Background: The odontogenic cysts are the most commonly occurring destructive lesions of jaws .The origin of these cysts is attributed to dental apparatus or developmental or inflammatory. However, the cysts of developmental origin show secondary changes to infection The degranulation of mast cells plays an important role in the pathogenesis of these cysts. Aims: The purpose of this study was to determine the mast cell density in different odontogenic cysts using special stain and its role in the pathogenesis of the cysts. Material and Methods: The retrospective study was carried out in archival paraffin embedded tissues of 10 histopathologically diagnosed cases of radicular cyst, dentigerous cyst and odontogenic keratocyst which were stained by haemotoxylin and subsequently by toluidine blue. The toluidine blue sections were evaluated under microscope at 400x magnification in 4 zones and results were compared . Results: The mast cell density was compared in all the four zones of these cysts and results were tabulated after statistical analysis. Conclusion: Based upon observations of present study it can be concluded that mast cells play an important role in expansion of cysts. Further studies on activation of mast cell products will impart a new diagnostic approach to researchers and will unmask the fascinating aspects of this cell

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