Material properties of chitosan from shells of Egeria radiata: Drug delivery considerations
Journal Title: Journal of Coastal Life Medicine - Year 2017, Vol 5, Issue 7
Abstract
Objective: To determine the material properties of chitosan derived from shells of Egeria radiata in the perspective of drug delivery. Methods: Chitosan was extracted from the shells of Egeria radiata by deproteination, demineralization, decolourization and deacetylation processes. The obtained chitosan was characterized by Fourier transform infra-red spectroscopy, scanning electron microscopy, X-ray diffraction spectrometry, X-ray fluorescence and degree of deacetylation. Results: The yield of chitosan from the shells was found to be 48.6%. The Fourier transform infra-red spectroscopy spectrum of obtained chitosan showed 12 major peaks between 660.62 and 3 642.57 cm–1 and specifically a band of large intensity at 1 485 cm–1 suggestive of effective deacetylation of chitin to chitosan. The scanning electron microscopy showed a nonhomogeneous particles distribution which became rougher as the magnification increased. The X-ray diffraction spectrometry revealed the presence of aragonite and coesite while the X-ray fluorescence showed heavy presence of calcium with intensity of 0.736 9 equivalent to 72% of total elemental composition. Titanium, lead, arsenic and other toxic elements were absent. The degree of deacetylation was found to be 67.8%. Conclusions: The derived polymer is a chitosan characterized by high calcium content showing that it could be more suitable for formulation of basic and neutral drugs. There is an indication of its suitability for bioadhesive drug delivery and permeation enhancement over a relatively wide pH range and also relatively limited use for sustained drug delivery.
Isolation of bioactive antioxidant compounds from the aerial parts of Allium roseum var. grandiflorum subvar. typicum Regel.
Objective: To assess the antioxidant activity of aerial parts of Allium roseum var. grandiflorum subvar. typicum Regel. (A. roseum var. grandiflorum subvar. typicum Regel.) for the first time, as well as to isolate the m...
The scale variation of barfi plaice Liopsetta pinnifasciata Kner, 1870 (Pleuronectidae, Pleuronectiformes)
Objective: To investigate the scales of barfin plaice (Liopsetta pinnifasciata), which depends on the size and sex of the fish. Methods: The samples were collected in Peter the Great Bay (Sea of Japan) during 2011–2014 a...
Screening potential genotoxic effect of aquatic plant extracts using the mussel micronucleus test
Objective: To assess the genotoxic potential of selected aquatic macrophytes: Ceratophyllum demersum L. (hornwort, family Ceratophyllaceae), Typha angustifolia L. (narrowleaf cattail, family Typhaceae), Stratiotes aloide...
Development of a sensor for the detection of Escherichia coli in brackish waters
Monitoring of bacterial pathogens is important for marine environmental protection, because the presence of these microorganisms can be a serious risk for human health. For this reason, a portable sensor implemented as a...
Screening for larvicidal activity of ethanolic and aqueous extracts of selected plants against Aedes aegypti and Aedes albopictus larvae
Objective: To screen for larvicidal activity of aqueous and ethanolic extracts (95% ethanol) from Selaginella elmeri, Christella dentata, Elatostema sinnatum, Curculigo capitulata, Euphorbia hirta, Murraya koenigii (M. k...