Mathematical model of evaluation of Insulin Resistance using Homeostasis Model Assessment – Insulin Resistance Index in patients with Hyperthyroidism
Journal Title: International Journal of Clinical Biochemistry and Research - Year 2017, Vol 4, Issue 4
Abstract
Aim: To evaluate insulin resistance using HOMA-IR index in patients with overt and subclinical hyperthyroidism. Materials and Method: A randomized case control study on female population was conducted. For which 30 overt hyperthyroid, 30 subclinical hyperthyroid and 30 age and sex matched Euthyroid controls were selected. Biochemical parameters like Total triiodothyronine (T3), Total Thyroxine (T4), Thyroid Stimulating Hormone (TSH), Fasting Insulin, Fasting Blood glucose were estimated from serum samples in auto analyzers. HOMA-IR Index was calculated using formula [Fasting insulin in uIU/ml × Fasting blood glucose in mg/DL / 405]. Statistical analysis was done using Graph pad prism software, parameters expressed in Mean ± SD, individual changes was assessed by students “t” test and Pearson’s coefficient of correlation was used. Results: HOMA-IR was significantly high in cases than control group (p<0.0001), Insulin levels were also high in cases compared to controls (p<0.0001). HOMA-IR index and Insulin levels were negatively correlated with TSH, in both overt and subclinical hyperthyroid cases than controls (r=0.97, p=0.0001 and r=0.45, p=0.001 respectively). Conclusion: Insulin resistance which was calculated by HOMA-IR index indicates the presence of insulin resistance in both overt and subclinical hyperthyroidism.
Authors and Affiliations
Thanuja N, K. Pratibha
Keywords
Related Articles
- EP ID EP298239
- DOI 10.18231/2394-6377.2017.0104
- Views 99
- Downloads 0
A Multi Marker Evaluation of Cardiovascular Disease Risk in Patients with Rheumatoid Arthritis
Background: Rheumatoid arthritis (RA), an inflammatory joint disease, is also associated with systemic effects. Patients with RA have an increased risk of morbidity and mortality that is mainly attributable to cardiovasc...
Establishment of reference interval for cord blood TSH
Introduction: TSH values in the cord blood is useful for neonatal screening of thyroid disorders. Screening is essential to rule out congenital hypothyroidism in neonates without any physical signs. In South Indian popul...
Study of serum nitric oxide (no) in type 2 diabetes mellitus patients having normoalbuminuria and microalbuminuria in Central India
Introduction: Nitric oxide (NO) is known as a mediator in a broad cluster of biological systems. NO is the endothelium-derived relaxing factor, which causes vasodilation by relaxing vascular smooth muscle. This role of N...
Evaluation of coagulation profile in patients suffering with type-2 diabetes mellitus: A hospital based prospective study
Introduction: T2DM and its complications develop due to uncontrolled plasma glucose levels for long time. Long term hyperglycemia will cause glycation of various tissue proteins. It also affects the coagulation process a...
Biochemical role of serum uric acid and cardiac enzymes in acute myocardial infarction
Introduction Acute myocardial infarction AMI remains a leading cause of morbidity and mortality worldwide In India cardio vascular disease is the leading cause of deathMaterials and Methods Itis a comparative study was c...