Matrix Metalloproteinase-2 as a Marker of Microvascular Complications in Children and Adolescents with Type 1 Diabetes Mellitus
Journal Title: Macedonian Journal of Medical Sciences (MJMS) - Year 2011, Vol 4, Issue 1
Abstract
Background. Patients with type 1 diabetes develop microangiopathic complications, which are responsible for morbidity in adulthood. It had been widely known that diabetes is associated with alteration in extracellular matrix (ECM) synthesis. Matrix metalloproteinases (MMPs) can potentially contribute to many microvascular and macrovascular complications of diabetes. MMP-2 is responsible for ECM breakdown and their abnormal circulating levels may pre-date clinical evidence of diabetic angiopathy. Aim of the work. Is to detect the plasma level and activity of matrix metalloproteinase-2, as a serum marker for diabetic vascular diseases, in type 1 diabetic children and adolescents and to identify its relation to the parameters of metabolic control and microvascular complications. Design. Cross section study including sixty children and adolescents with type 1 diabetes mellitus with age range from 7 to 18 years. They were divided into two groups according to diabetic duration. Group I: Thirty patients with diabetes duration less than 5 years ranging from 8 months to 3 years with a mean duration of 1.66 ± 0.75 years. Group II: Thirty patients with diabetes duration more than 5 years ranging from 5 to 14 years with a mean duration of 7.7 ± 2.84 years. Thirty healthy children and adolescents of comparable age, served as controls. Diabetic patients were also divided according to microvascular complications into complicated (n=27) and non complicated (n=33). All patients and controls were subjected to history taking, thorough clinical examination and laboratory investigations included; random blood sugar, glycosylated hemoglobin (HbA1c), quantitative determination of urinary microalbumin, fundus examination and measuring of plasma matrix metalloproteinase-2 levels (using ELISA) and activity.
Authors and Affiliations
Mai M Yossef| Child Health Department, National Research Center, El-Tahrer st. Giza, El-Bohose 125439, Egypt, Hoda A Megahed| Medical Biochemistry Department, National Research Center, El-Tahrer st. Giza, El-Bohose 125439, Egypt, Sawsan Tawfik| Child Health Department, National Research Center, El-Tahrer st. Giza, El-Bohose 125439, Egypt, Hanaa El Sherif| Medical Biochemistry Department, National Research Center, El-Tahrer st. Giza, El-Bohose 125439, Egypt, Ola Mohy Eldin| Child Health Department, National Research Center, El-Tahrer st. Giza, El-Bohose 125439, Egypt, Manal A Mohsen| Child Health Department, National Research Center, El-Tahrer st. Giza, El-Bohose 125439, Egypt, Nagham M El-Beblawy| Pediatric Department, Faculty of Medicine, Ain Shams University, Egypt, Amira AM Adly| Pediatric Department, Faculty of Medicine, Ain Shams University, Egypt
Keywords
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- EP ID EP8790
- DOI 10.3889/MJMS.1857-5773.2011.0151
- Views 321
- Downloads 14
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