Mechanisms of Host Resistance Against HIV Infection and Progression to AIDS
Journal Title: Sultan Qaboos University Medical Journal - Year 2007, Vol 7, Issue 2
Abstract
Since the discovery in the early eighties of the Human Immunodeficiency Virus (HIV) that causes acquired immunodeficiency syndrome (AIDS), there have been reports of people who were completely resistant to infection with HIV and others who progressed at slower rates to AIDS. Te present article summarises the mechanisms involved in resistance against HIV infection and progression to AIDS. Te paper will specifically focus on the role of immunological mechanisms, genetics, ethnicity and cultural practices such as male circumcision in mitigating infection. Te current understanding on host natural resistance against HIV infection and progression to AIDS would potentially contribute to better prevention strategies, delayed onset of AIDS in people living with HIV, the identification of more efficient types of therapy for AIDS patients and, possibly, appropriate vaccines against HIV/AIDS. Tis area of research has important implications for patient care through controlling factors that contribute to AIDS progression.
Authors and Affiliations
Ali A Al-Jabri| Department of Microbiology & Immunology, College of Medicine & Health Sciences, Sultan Qaboos University, P.O. Box 35, PC 123, Al-Khod, Muscat, Sultanate of Oman
Keywords
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